Personally, if I see a community I am not interested in, I also block it, nothing personal, as I am here more for the memes and technical posts. Helps sanitizing my feed somewhat.
But regarding replacement instances, personally, I would suggest not putting all your bets in any specific ones and instead having alts in them and bookmarking them so you can hop to the next one quickly if the current one starts getting to your nerves or if it becomes unusable for over a week or something.
Which instance?
So, wading through the illegal prescription drug spam to post this....