ttpphd,
@ttpphd@mastodon.social avatar

Study shows heightened sensitivity to PTSD in autism

Parvalbumin interneuron activity in autism underlies susceptibility to PTSD-like memory formation
Abed et al., 2024, iScience

"ASD and PTSD share common features, including impaired emotional regulation, altered explicit memory, and difficulties with fear conditioning.

“We demonstrated in four mouse models of ASD that a single mild stress can form a traumatic memory.” "

https://qbi.uq.edu.au/article/2024/05/study-shows-heightened-sensitivity-ptsd-autism

alex,
@alex@digittante.com avatar

@ttpphd

What is "difficulties with fear conditioning"? Like, the mouse doesn't become fearful of stimuli that should reasonably scare?

ttpphd,
@ttpphd@mastodon.social avatar

@alex

Here's the follow up comment from the researcher: “We demonstrated in four mouse models of ASD that a single mild stress can form a traumatic memory.”

“In a control population, on the other hand, PTSD is triggered by extreme stress.”

So it sounds like ASD mouse model showed more extreme fear conditioning.

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