My initial thoughts when posting the OP were something like “When the decision against a male antagonist is made, there’s a higher probability of the baddie also having a more original motivation.” However, others have rightly said that just changing the gender of male BBEGs already gives opportunity for some great ideas inspired by such thought experiments. And my general idea when writing the OP isn’t too valid, either. Should have been less fixated on gender and more straightforward that what I’m looking for are unique personalities and original motivations of antagonists unlike the classics money, power, dogma.