Yes, my wife and I have been doing it since 2016 (with a break in 2020/2021 for obvious reasons).
Usually stay in short-rental apartments rather than hotels as with two people it’s usually cheaper than a hotel or hostel, given weekly and monthly discounts that are common.
Most airlines used to have 10kg included but now for most it’s gone down to 7kg so we’ve had to get more creative. 5 shirts, 2 pants (one zip-off for swimming), 8 pairs of underwear and 5 pairs of socks, 2 sweaters. Small bag of toiletries. Winter jacket, thermals, gloves (good enough for Hokkaido in the early spring). Do washing once a week when it’s cold, twice when it’s hot. Heaviest thing is of course my laptop & brick. Changed bag to a thin canvas one to reduce weight further when the size/weight restrictions went down. Some airlines (such as Ryanair) don’t even let you use the overhead bins for free so the bag has to fit under the seat in front.