I believe the most important phrase in science in coming decades will be "ontological shock." Our approach to scientific advancement thus far has largely focused on observing matter and energy at micro and macro scales, but it is clear that observation alone does not explain the behavior of said matter and energy.
In quantum mechanics, we see we do not understand the behavior of the tiniest constituents of matter.
In our observation if distant galaxies, we see we don't understand the nature of matter on a macro scale (ie: socalled "dark matter).
We have reached our limit of understanding by looking only at matter as a physical phenomenon, and we are on the brink of a new paradigm that will upheave everything we thought we knew.
This will overhaul our understanding of the nature of spacetime, quantum fields, and consciousness, through a "nonlocal" lens.