mihair
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mihair

@mihair@kbin.social

I am ambitious and motivated. I enjoy challenges and constantly set goals for myself, so I have something to strive towards. I don't feel comfortable when I'm not evolving and I'm always looking for an opportunity to do more good and achieve greatness.

mihair, to science
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mihair, to animals
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mihair, to science
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Stevia is considered a "natural non-caloric sweetener." Saccharin and sucralose are considered "non-nutritive sweeteners" (few or no calories). Aspartame is a "nutritive sweetener" (adds some calories but far less than sugar).
Aspartame comes with a warning to be used cautiously (or not at all) by people with a rare genetic disease (called phenylketonuria, or PKU) because they have trouble metabolizing it; that's not true for the other sweeteners. And all four vary on their level of sweetness and aftertaste, which is likely why people often prefer one over another.

https://www.health.harvard.edu/blog/sweeteners-time-to-rethink-your-choices-2019022215967

mihair, to science
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With a low to no calorie sugar count, artificial sweeteners may seem like a treat for people with diabetes. But recent research indicates that artificial sweeteners may actually be counterintuitive, especially if you’re looking to manage or prevent diabetes.
In fact, the increased consumption of these sugar substitutes may correlate to the increase of obesity and diabetes cases.

https://www.healthline.com/health/type-2-diabetes/diabetes-stevia#overview

mihair, to science
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Stevia is an ideal replacement for traditional sugar, especially if you have diabetes or a carbohydrate-controlled diet. That way, you can enjoy sweet foods without dealing with diabetic complications. Unlike normal sugar made of sucrose, stevia contains stevioside. It is a glycoside compound, not a carbohydrate. Table sugar is absorbed into the bloodstream. As stevioside breaks down, the glucose is absorbed in the colon by bacteria.

https://facty.com/food/nutrition/10-surprising-benefits-and-risks-of-the-alternative-sweetener-stevia/?style=quick&utm_source=adwords&adid=267723668343&ad_group_id=57749014289&utm_medium=c-search&utm_term=stevia&utm_campaign=FH-USA-Search-Health-Benefits-and-Risks-of-Stevia&gclid=EAIaIQobChMI1v_2gJqCgQMV1gQGAB1JAgLjEAAYAyAAEgL1VvD_BwE

mihair, to science
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Pancreatic cancer has an extremely poor prognosis, largely due to a poor record for early detection. Known risk factors for pancreatic cancer include obesity, diet, and diabetes, implicating glucose consumption and regulation as a key player. The role of artificial sweeteners may therefore be pertinent to disease kinetics. The oncogenic impact of artificial sweeteners is a highly controversial area.
https://www.frontiersin.org/articles/10.3389/fonc.2017.00018/full

mihair, to science
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Stevia, a zero-calorie sugar substitute, is recognized as safe by the Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). In vitro and in vivo studies showed that stevia has antiglycemic action and antioxidant effects in adipose tissue and the vascular wall, reduces blood pressure levels and hepatic steatosis, stabilizes the atherosclerotic plaque, and ameliorates liver and kidney damage. The metabolism of steviol glycosides is dependent upon gut microbiota, which breaks down glycosides into steviol that can be absorbed by the host. In this review, we elucidated the effects of stevia’s consumption on the host’s gut microbiota.
https://www.mdpi.com/2076-2607/10/4/744/htm

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To help offset potential stevia induced gut challenges, support your gut flora with fiber and prebiotics like FOS10 (fructo-oligosaccharides). Increase your intake of beneficial bacteria Lactobacillus and Bifidus to aid in a healthier gut microbiome.
Consider foods and nutrients like cruciferous vegetables (Brussels sprouts, cabbage, broccoli, cauliflower, kale), silymarin, dandelion, resveratrol, curcumin, magnesium, zinc, limonene, B vitamins, and omega-3 oils to help your liver’s glucuronidation pathway.

https://www.bbc.com/mundo/noticias/2013/07/130717_salud_nutricion_stevia_finde_gtg

mihair, to science
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Ancestral intake of the raw stevia leaf was extremely limited compared to current exposures of refined stevia found in many manufactured food products. I am a proponent of using foods in their natural, whole form when possible.
Avoid processed refined sugars and foods with added sugars, but rather use raw local honey, blackstrap molasses, real maple syrup, or other natural sugars. Think about it, would your grandmother or great grandmother use something like refined stevia in their made from scratch homemade recipes?

https://medlineplus.gov/spanish/druginfo/natural/682.html

mihair, to science
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Artificial sweeteners or intense sweeteners are sugar substitutes that are used as an alternative to table sugar. They are many times sweeter than natural sugar and as they contain no calories, they may be used to control weight and obesity. Extensive scientific research has demonstrated the safety of the six low-calorie sweeteners currently approved for use in foods in the U.S. and Europe (stevia, acesulfame-K, aspartame, neotame, saccharin and sucralose), if taken in acceptable quantities daily. There is some ongoing debate over whether artificial sweetener usage poses a health threat .This review article aims to cover thehealth benefits, and risks, of consuming artificial sweeteners, and discusses natural sweeteners which can be used as alternatives.

https://pubmed.ncbi.nlm.nih.gov/25842566/

mihair, to science
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Stevia rebaudiana Bertoni is a perennial shrub with zero calorie content that has been increasing in popularity for its potential use as an adjuvant in the treatment of obesity. The level of evidence supporting general benefits to human health is insufficient. We conducted a review of the literature summarizing the current knowledge and role in human disease.
A growing body of evidence indicates that Stevia rebaudiana Bertoni is protective against malignant conversion by inhibition of DNA replication in human cancer cell growth in vitro.

https://pubmed.ncbi.nlm.nih.gov/29995279/

mihair, to science
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Gustul ceaiului de kombucha diferă de la un producător la altul în funcție de metodele de preparare. Tocmai de aceea vă invităm să testați cele 8 sortimente iKombucha. După o experiență de peste 7 ani în producerea de kombucha, am adăugat la rețetele noastre stevia ca și îndulcitor, pentru ca produsul final să nu fie prea acru la gust pentru majoritatea clienților. Am dezvoltat 8 sortimente cu diferite arome, care să acopere înr-o anumită măsură gustul de ferment și să ofere gusturi plăcute.

https://healthfully.com/stevia-and-cancer-5918164.html

mihair, to science
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Stevioside is a diterpene glycoside found in the leaf of Stevia rebaudiana, a traditional oriental medicinal herb, which has been shown to have various biological and ethno-medicinal activities including antitumor activity. In this study, we investigated the effects of stevioside on the cytotoxicity, induction of apoptosis, and the putative pathways of its action in human breast cancer cells (MCF-7). For the analysis of apoptotic pathway, measurement of reactive oxygen species (ROS) and assessment of mitochondrial transmembrane potential (MTP) were achieved. We showed that stevioside was a potent inducer of apoptosis and it conveyed the apoptotic signal via intracellular ROS generation; thereby inducing change in MTP and induction of mitochondrial mediated apoptotic pathway. Taken together, our data indicated that stevioside induces the ROS-mediated mitochondrial permeability transition and results in the increased expression of apoptotic proteins such as Bax, Bcl-2 and Caspase-9. Effect of stevioside on stress-related transcription factors like NF-E2-related factor-2 opens up a new vista for further studies. This is the first report on the mechanism of the antibreast cancer (in vitro) activity of stevioside.

https://pubmed.ncbi.nlm.nih.gov/23061910/

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A β-galactosidase from Kluyveromyces lactis was found to specifically catalyze hydrolysis of the glycosyl ester linkage of stevioside to yield steviolbioside, a rare sweetener that also exists in Stevia rebaudiana leaves. In a packed bed reactor, a reaction coupling separation was realized and a production yield of steviolbioside reached 90% in 6 h. The hydrolysis product steviolbioside presented higher cytoxicity on human normal cells (hepatocytes cell L02 and intestinal epithelial cell T84) than stevioside did. Comparing to the typical chemotherapy agent, 5-fluorouracil (5-FU), steviolbioside presents much lower cytotoxicity on all assayed human normal cells; it presented notable inhibition on human hepatocarcinoma cell Hep3B, human breast cancer cell MDA-MB-231 and human pancreatic cancer cell BxPC-3. The remarkable inhibition on MDA-MB-231 cells makes steviolbioside a potential remedy for human breast cancer, when steviolbioside is served as a natural sweetener.

https://pubmed.ncbi.nlm.nih.gov/26593477/

mihair, to science
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Regarding nutritional benefits, the available studies, while numerous, do not provide proof that the consumption of artificial sweeteners as sugar substitutes is beneficial in terms of weight management, blood glucose regulation in diabetic subjects or the incidence of type 2 diabetes. Regarding nutritional risks (incidence of type 2 diabetes, habituation to sweetness in adults, cancers, etc.), it is not possible based on the available data to establish a link between the occurrence of these risks and the consumption of artificial sweeteners. However, some studies underline the need to improve knowledge of the links between intense sweeteners consumption and certain risks.

https://pubmed.ncbi.nlm.nih.gov/26430511/

mihair, to science
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The essential oil extracted by hydrodistillation from the flowering twigs of Stevia rebaudiana Bertoni (Asteraceae) was fractioned by chromatography. Forty-three constituents were characterized with the help of GC, GC-MS and other spectroscopic techniques. The essential oil was found to be a complex mixture of mono- and sesqui-terpenes. The cytotoxicity of the essential oil and its fractions was evaluated by sulforhodamine B (SRB) based assay against two cancer cell types viz. C-6 (rat glioma cells) and CHOK1 (Chinese hamster ovary cells). The essential oil and its fractions showed promising cytotoxicity against both cell lines. The highest activity (95.6+/-0.6%) was show by the essential oil on the C-6 cell line at a concentration of 400 microg/mL, which was comparable with that of the standard drug vinblastin.

https://pubmed.ncbi.nlm.nih.gov/25026731/

mihair, to science
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Stevia, a zero-calorie sugar substitute, is recognized as safe by the Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). In vitro and in vivo studies showed that stevia has antiglycemic action and antioxidant effects in adipose tissue and the vascular wall, reduces blood pressure levels and hepatic steatosis, stabilizes the atherosclerotic plaque, and ameliorates liver and kidney damage. The metabolism of steviol glycosides is dependent upon gut microbiota, which breaks down glycosides into steviol that can be absorbed by the host. In this review, we elucidated the effects of stevia's consumption on the host's gut microbiota. Due to the lack of randomized clinical trials in humans, we included in vitro using certain microbial strains and in vivo in laboratory animal studies. Results indicated that stevia consumption has a potential benefit on the microbiome's alpha diversity. Alterations in the colonic microenvironment may depend on the amount and frequency of stevia intake, as well as on the simultaneous consumption of other dietary components. The anti-inflammatory properties of stevioside were confirmed in vitro by decreasing TNF-α, IL-1β, IL-6 synthesis and inhibiting of NF-κB transcription factor, and in vivo by inhibiting NF-κB and MAPK in laboratory animals.

https://pubmed.ncbi.nlm.nih.gov/35456796/

mihair, to science
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Steviol glycosides (SGs) in Stevia (Stevia rebaudiana Bertoni) leaves are important due to their high sweetness and low calorific value. The yield of SGs is dependent on fertilization regimes, but the relationship between nitrogen (N) administration and SGs synthesis is still unclear. In this study, we investigate the effects of N rates on SGs production through hydroponic and plot experiments. The SGs yield was not significantly changed by N fertilization, but leaf SGs concentrations were significantly reduced due to the "dilution effect". Additionally, N addition decreased leaf carbon (C)/N ratio and soluble sugar concentration, accompanied with the inhibited phosphoenolpyruvate carboxylase and L-phenylalanine ammonia_lyase activities. A significant positive correlation between leaf SGs concentrations, C/N ratio and soluble sugar concentration was observed. Overall, we suggest that N-driven Stevia growth negatively affects SGs concentrations. The leaf C/N ratio and soluble sugar changes indicated the occurrence of metabolic reprogramming.

https://pubmed.ncbi.nlm.nih.gov/31195254/

mihair, to science
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Plant growth and secondary metabolism are commonly regulated by external cues such as light, temperature and water availability. In this study, the influences of low and high temperatures, dehydration, photoperiods, and different growing stages on the changes of steviol glycosides (SGs) contents and transcription levels of fifteen genes involved in SGs biosynthesis of Stevia rebaudiana Bertoni were examined using HPLC and RT-PCR. The observations showed that the transcript levels of all the fifteen genes were maximum under 25 °C treatment, and the transcription of SrDXS, SrDXR, SrMCT, SrCMK, SrMDS, SrHDS, SrHDR, SrIDI, SrGGDPS, SrCPPS1, SrUGT85C2 and SrUGT76G1 were restrained both in low temperature (15 °C) and high temperature (35 °C). Most genes in SGs biosynthesis pathway exhibited down-regulation in dehydration. To elucidate the effect of photoperiods, the plants were treated by different simulated photoperiods (8 L/16 D, 1 0L/14 D, 14 L/10 D and 16 L/8 D), but no significant transcription changes were observed. In the study of growing stages, there were evident changes of SGs contents, and the transcript levels of all the fifteen genes were minimal in fast growing period, and exhibited evident increase both in flower-bud appearing stage and flowering stage. The obtained results strongly suggest that the effect of environmental cues on steviol glycosides contents and transcription of corresponding biosynthetic genes in S. rebaudiana is significant. It is worth to study deeply.

https://pubmed.ncbi.nlm.nih.gov/25500454/

mihair, to music
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Are plants not the stars of the Earth?
Plants meditate all the time. Because they simply give up on themselves and accept the sun's rays and raindrops. Contemplate the rainbow. I feel the joy of the wind and the feelings that the Earth sends. - Arjun Das
Plants are part of the Plantae Kingdom. The kingdoms, in turn, were divided into smaller and smaller units as: branch, Class, Order, family, genus, species. In addition to these, in some cases, intermediate systematic units, such as sub-branch, superclass, etc.the name of plant species, like the name of other species of organisms, is made using binary nomenclature.
Mainly plants are divided into two broad categories – simple plants without flowers, and flowering plants.
Plants without flowers
The simplest plants without flowers are algae. Almost all species of algae live in water, but there are also a few that can survive in damp places, for example, the pleurococcus alga, which grows like a greenish powder on the shady trunks of trees. Most of the plants that live in the waters of the seas and oceans are algae, as are some of those in fresh waters, such as Frog silk. Algae do not have true roots, stem and leaves, although they may have segments that resemble stems and leaves. They absorb water and mineral salts through the entire surface of the body.
Some plants reproduce by spores-very small, dust-like grains, from which new plants develop. Conifers, also called gymnosperms, reproduce by seeds. They form inside hard structures, formed by scales, called cones. Firs, spruces, pines, Larches and cypresses are conifers.
All coniferous species are trees or shrubs. Most of them have long narrow leaves (needles) that do not fall off in autumn.
Flowering plants
Flowering plants are known as angiosperms. Flowers are parts of the plant specialized for reproduction. They produce seeds, which, when hit under favorable conditions, sprout and form a new plant. Flowering plants are the dominant group of plants everywhere on Earth, except for algae in the seas and oceans and coniferous forests in cold areas of the globe. Among the flowering plants are all species of grasses, Reed, rushes, garden flowers and wildflowers, along with most trees and shrubs (except conifers). There are 260,000 different species of flowering plants, compared to 550 species of conifers, 11,000 Ferns, 23,000 mosses and about 12,000 species of algae.
Tuberoses are flowers with impressive beauty and fragrance, which makes them one of the most popular decorative flowers in the world. In addition, these flowers are also known for their beneficial properties for health.
Tuberoses are a rich source of important nutrients for health. They contain a multitude of vitamins, minerals and antioxidants, which help maintain and improve our health. Among the benefits of eating tuberose are: improving digestion, reducing inflammation, regulating blood sugar levels, strengthening the immune system and reducing the risk of heart disease. Also, tuberoses are a good source of fiber, which makes them beneficial for maintaining the health of the intestinal tract.
In conclusion, regular consumption of tuberose can bring numerous benefits to our health and can be successfully included in our daily diet.
Gene expression is the process in which a plant's DNA code is translated into instructions for biological processes such as growth. Our plants, including tuberoses kept in an environment without sunlight, responded to sound waves. At 125Hz and 250Hz sounds rbcS and Ald genes are created, which are known for responding to light, while more active sound waves at 50Hz made these genes less active.
So wherever we are our flowers are a friend that we can visit at any time. Thank you we are grateful/grateful and we apologize! Even the smallest and smallest plants can have some of the strongest roots.

mihair, to animals
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In memory of our beloved Titilica

Since the world and the Earth the fluttering, the flight and the singing of birds awaken in the soul of man not only a whole range of experiences and sufferings, but they are interwoven so much with the life of man that they form a whole whole.
Titilica you are among the beings who bring such a great light to the world that even after they have left the light remains.
The flight of every bird
it's an exercise imposed,
their wings search for the unquenchable
to gather him in a hug.
Always be
a flight of a wing
a flight in a hug...( Violeta Pasat)
Your hatred took flight, making you sick. However we cannot and will not forget everything you have done for us and the beings who have come near you including those of your species. All of us and you treated us with great love. Memories of and of you will never fade.
You, Titilica, whom we held in our arms for a short time we hold in our hearts forever.The fact that you are no longer here will always cause us pain, but you are forever in our hearts until we meet again.
When you left, we felt like we had lost part of our own body. It's like taking us with you, with all the pain of losing someone we never thought we'd lose.
So losing a loved one is painful, but losing yourself is even worse, because you are the most beloved of all. You should come back to our side, please stay longer this time, okay?

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