Unfortunately I don’t believe NumPy has any built in accelerations (other than being a C library which is fast already), though I don’t really know the ins and outs. There are Python libraries that use the NumPy API or otherwise do some stuff to accelerate it on e.g. CUDA, but the Numpy.NET library as far as I know uses its own embedded Python + numpy, so as far as I can tell that wouldn’t be an option.