No idea if Gotosocial supports relays or not, which is my choice of software so far. There seems to be some incompatiblilty between gup.pe and GTS (alpha software and all, expected issues obviously) so those are a no-go as well.
Following accounts are fine, but it’s really the creation part that causes issues. Unless you go full on reply guy, and I have at least some sliver of shame left in my body to not go full reply guy.