kennethbaillie

@kennethbaillie@critcare.social

I'm an intensive care doctor, working to understand and treat critical illness using genomics

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jopo_dr, to random

What does the is community think about selective decontamination? I think the evidence is stronger than for some of the things we do, but it doesn’t feel like it should work (then in detail, looking at immune cross talk and second hits, maybe it does!)

kennethbaillie,

@PieterPeach @jopo_dr It's a very interesting story. Strong evidence for net benefit, but limited uptake. I think it is reasonable to consider that generalisability (in both space and time) will be limited because of the nature of the intervention, but I can't think of another reason not to do it.

iwashyna, to random

So Fringe and the Book Festival both happen the same week…

kennethbaillie,

@iwashyna That is correct! The population of the city doubles for that month. Accommodation can be a challenge but I can help there :)

kennethbaillie,

@iwashyna Let me know when you’re in town! We might even persuade @Charlotte_Summers to drop in for a beer

kennethbaillie, to random

trial presented just now. Stopped early for emphatic efficacy on primary endpoint: videolaryngoscopy halved the rate of failed intubation at first attempt compared with direct laryngoscopy.

Interestingly, although underpowered to detect a difference due to lower event rates, there was no difference in complications

kennethbaillie,

Here’s the paper: https://www.nejm.org/doi/full/10.1056/NEJMoa2301601

Key observation from editorial: videolaryngoscopy benefit is evident only with less experienced operator

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