Already daily driving it on my laptop, which uses AMD graphics, and my work laptop, which uses Intel graphics. For Nvidia, there’s missing explicit sync (which should be fixed soon), and Steam completely freaking out (might get fixed by explicit sync). Kwin also seems a bit unstable on Nvidia, but I haven’t tested it for extended periods of time.
I also have a computer with display on an Nvidia card via reverse prime, which suffers performance issues on Wayland. Might be improved on Plasma 6, but that computer runs OpenSUSE Leap, so it won’t get that for some time.
There is also the issue of picture-in-picture, but that can be worked around with Kwin rules.