Going back to Konversation for GUI stuffs. DCC file send/receive is kinda important to me. For everything else, including a lot of Matrix usage, WeeChat is still the Kewlist :p
Honorable mention goes to Halloy, which I think looks really good, supports tiling, and says it supports DCC Send - I don't mind manipulating config files by hand, and I might check it out with a FlatPak, but if I'm sufficiently impressed it looks like I'll have to build the .deb and SlackBuild myself, ... Well? Somebody's got to! Right?