Jarlsburg

@Jarlsburg@lemmy.world

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Jarlsburg,

I played Like a Dragon with no background and it was a great experience. Really wacky in a satisfying way. Only grievance is there is ~10 hours of cut scenes to beat the game.

Jarlsburg,

When I was in secondary school I had to fill out a form over the summer to be allowed to leave early for some school activities. The form required a coach or teacher’s signature. Since it was the summer, I had no contact with any faculty so I had my parents call the coach who told me to sign the form for him, which I did and I turned it in. Unfortunately, that coach left before the beginning of the year so when school started I was called to the principal’s office and accused of forging his signature. I told the principal the coach told me to, so it wasn’t a forgery, I was signing on his behalf, and I even put that on the form. He ended up calling the coach and he even confirmed but at that point he didn’t want to back down and still denied the request.

After I left the two older ladies that ran the office found me and told me they just approved it after he left for the day and he would never know. They were super nice and told me they were proud of me for sticking up for myself. As a barely out of primary school kid it was really intimidating to be yelled at by an adult but I felt so vindicated when they recognized the inequity of the situation and helped me.

That principal ended up only lasting a year too.

Jarlsburg,

Hell yeah.

I never experienced homelessness but I was lonely growing up. I remember meeting a new kid at school and and we played Earthbound until 3am on his SNES and fell asleep feeling like I was floating because I found a friend and a cool game.

That said It was also the day I saw Starship Troopers in theaters and saw boobs for the first time so that may have been contributory. All in all though banner day.

Jarlsburg,

As someone who has been in the 3d printing space for awhile, I am amazed at how cheap and featured the entry level printers are. For ~$150 you can get a printer with auto bed leveling and a magnetic bed. At $15/lb of filament, you only need a few projects to pay for itself.

For example, I printed the housing for a USB hub for a friend which is a clone for a ridiculously expensive one that fits Lovesac couches and he paid me $50. It cost ~$2 of filament and ended up printing a few more for others. That alone paid for the cost of the printer.

For anyone who is thinking about it, now is a great time to enter the hobby.

Jarlsburg, (edited )

Justified hate for EA aside, I really don’t mind unobtrusive product placement in games or media. Take The Boys for example, they have heavy product placement in the show (Fresca, Kraken rum, Adidas, etc.) but it didn’t detract from the narrative and I think the casual viewer didn’t even notice it.

I have no faith whatsoever EA will be able to keep themselves from hamfisting ads in the player’s face, but I am not categorically against the idea.

Jarlsburg,

No one has given you an actual reply just assuming that the manufacturing costs for the drug are low. Zolgemsma is a modified version of adeno associated virus and has to be grown under specific conditions. It costs $500k-$1m per production.

Jarlsburg,

Zolgemsma is a modified version of adeno associated virus and has to be grown under specific conditions. It costs $500k-$1m per production.

Jarlsburg,

Zolgemsma is a modified version of adeno associated virus and has to be grown under specific conditions. It costs $500k-$1m per production.. It’s also a one time injection that functionally cures the person of the disease. There are a couple other options but for comparison, the other therapeutic is Spinraza which is an intermittent intrathecal infusion which is $805,000 for the first year of therapy and $380,000 per year thereafter for the rest of your life.

To be clear, I think we should bear the actual costs of research, development, and manufacture as a society and not profiteer off the sick, but there are some contributory reasons for the price.

Jarlsburg,

I commented this elsewhere, but to answer your question,

Zolgemsma is a modified version of adeno associated virus and has to be grown under specific conditions. It costs $500k-$1m per production. It’s also a one time injection that functionally cures the person of the disease. There are a couple other options but for comparison, the other therapeutic is Spinraza which is an intermittent intrathecal infusion which is $805,000 for the first year of therapy and $380,000 per year thereafter for the rest of your life.

SMA type I also is 100% fatal by year 2-3 and the baby dies without being able to even lift their head. It’s a terrible prognosis.

To be clear, I think we should bear the actual costs of research, development, and manufacture as a society and not profiteer off the sick, but there are some contributory reasons for the price.

Jarlsburg,

Bit of a stretch of the definition of a JRPG, but Final Fantasy Tactics and/or Tactics Ogre.

Jarlsburg,

I know I am late to the original conversation but that show awakened my children to numbers and math so much so they stole the calculator out of my office to play with at bedtime.

Jarlsburg,

I would say Robin Hobb. She writes easy to read, character driven fantasy novels that gracefully deal with a gamut of difficult topics (e.g., orphanism, otherness, sexual violence, mortality, etc.). The books really helped me build empathy for people and concepts that were far afield of my own experience.

Jarlsburg,

I used a coiled cable and put my audio interface to my side higher up on a shelf. That way when I am seated the headphone cable barely touched the ground.

Jarlsburg,

It sounds odd but there was a Supreme Court about it. Essentially someone claimed they shouldn’t have to pay taxes on the profits of crime and the Court ruled they did. So they had to create a way for people to do that. For what it is worth, the 5th amendment protects you from incriminating yourself, so you are allowed to decline to provide the details of where the money came from, but it’s a bit like paying your parents for something you broke and then just not telling them what it is, and then expecting them not to look around the house.

“it would be an extreme if not an extravagant application of the Fifth Amendment to say that it authorized a man to refuse to state the amount of his income because it had been made in crime. … He could not draw a conjurer’s circle around the whole matter by his own declaration that to write any word upon the government blank would bring him into danger of the law.” … "It is urged, that, if a return were made, the defendant [Sullivan] would be entitled to deduct illegal expenses, such as bribery. This by no means follows, but it will be time enough to consider the question when a taxpayer has the temerity to raise it.”

United States v. Sullivan, 274 U.S. 259 (1927)

Jarlsburg,

Yeah there’s a logical inconsistency for sure, but I see the practical necessity of it.

Jarlsburg,

Mentor children.

It only takes about an hour a week and once you establish a relationship with them you just bring them along when you are doing something fun anyway. You feel a sense of purpose and they fare better in nearly every measurable statistic of emotional well being and academic success. Men in particular are needed to mentor young men and can have the greatest impact. Many organization will match you with a kid who has your same interests too so you’re just doing stuff you both like. I really can’t recommend it enough.

Jarlsburg,

That’s true but the difference is exceedingly small.

According to 1 FDA study, the mean difference for AUC values between test and reference products was found to be 3.5% in the 2-year period following the Waxman-Hatch Act, and 80% of the absolute differences between generic products approved since 1984 and the corresponding innovator products were within a 5% range.

Debunking a Common Pharmacy Myth: The 80-125% Bioequivalence Rule Jun 8, 2016

What's your favorite game that you will NEVER finish?

This question popped into my head when I was playing Void Stranger. I just got done with the game and will probably never play it again despite not finishing it. The game is genuinely amazing but it just gets so demanding as you progress through it. I ended up watching the second half of the game on YouTube....

Jarlsburg,

Nethack is like the Jumanji of games. You finish it by introducing someone else to it.

Jarlsburg, (edited )

You absolutely must play Doki Doki Literature Club if you have not. It’s free. Do not look up spoilers or be put off by the type of game or the setting. Just play it.

P.S. - “Doki Doki” the way you write the sound of a heart beating in Japanese akin to “lub dub” in English.

Jarlsburg,

I worked at a pharmacy and the only time it actually happened was when a patient tried to sell their Vicodin to an undercover cop outside the store. The cop came in and asked for the information about the prescription and we gave it to him.

Jarlsburg,

Yeah, I didn’t say any of that but ok. HIPAA/employers actually require you to give law enforcement information in a variety of situations, including specifically the situation I mentioned:

To report PHI that the covered entity in good faith believes to be evidence of a crime that occurred on the covered entity’s premises (45 CFR 164.512(f)(5)).

HHS - When does the Privacy Rule allow covered entities to disclose information to law enforcement

Jarlsburg,

Yes, without a warrant. It’s in the Privacy Notice in any retail pharmacy.

Impersonating a cop is a pretty big step that’s illegal in its own right but we did have moms trying to see if their adult daughter was on birth control, but that’s pretty easy to stop. Just lock their profile and ask the patient to make up a passcode or only deal with them in person.

Jarlsburg,

The HIPAA Privacy Rule exception for law enforcement purposes, 45 CFR § 164.512(f), permits a covered entity (generally, healthcare providers, health plans and their business associates) to disclose PHI to law enforcement officials without patient authorization under certain circumstances.

Those pharmacies also have this exception listed in their Privacy Policy. I don’t like it either, but it is legal.

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