skillissuer

skillissuer, 1 hour ago

spoiler looks like this on lemmy, maybe that format works only for your app

<span style="color:#323232;">
</span><span style="color:#323232;">::: spoiler spoiler
</span><span style="color:#323232;">content
</span><span style="color:#323232;">:::
</span><span style="color:#323232;">
</span>

spoilercontent

skillissuer, 2 days ago

they are the same wankers

skillissuer, 4 days ago

Girkin is in jail, you know, so now they have issues shooting down civilian aircraft

skillissuer, 4 days ago

this sounded weird so i looked it up, and it seems to be a sort of mistranslation, iranian soldiers were given a booklet of pamphlets called “Keys to Paradise” along their dogtags en.wikipedia.org/wiki/Plastic_key_to_paradise

skillissuer, 5 days ago (edited 5 days ago)

from few encounters it really seems like he dips into the void for weeks randomly. after he wanted to have something explained over matrix he didn’t reply for like two four months. really taking instant out of instant messaging

skillissuer, 6 days ago

legally, that’s not news

skillissuer, 8 days ago

we have mkultra at home

on the other hand, that’s just speedrunning being jordan peterson

on the third hand, our very good friend apparently never had been drunk

on the fourth hand, our very good friend also didn’t clock that maybe his ability to assess his own mental state was disturbed (it was) (severely)

on the fifth hand, this is an effect of many drugs, iv line suggests midazolam but maybe ketamine was an option. neither are exactly easily available for regular civilian (other benzos are)

first principling that benzos are completely safe, yeah way to go, 10/10. also not their first rodeo, but lwers on drugs would be megaminds on adderal, at least that’s what could be noticed previously

skillissuer, 7 days ago

this is peak 18-century science

skillissuer, 7 days ago

it’s a known issue …wikipedia.org/…/Kindling_(sedative–hypnotic_with…

skillissuer, 7 days ago

that’s a very carefully worded comment. there’s a reason why benzos were commonly prescribed in the past (but less so now)

skillissuer, 7 days ago

it sounds like what they’re trying to do is Wada test, for no particular reason, with zero knowledge what they’re trying to do or what tools do they need for that

about everything what could they learn from that is already described in psychiatry and psychology textbooks, but it’s too hard for homeschooled first-principlers like them

skillissuer, 7 days ago

at least crypto isn’t involved this time. few understand (real world economics)

skillissuer, 5 days ago

it does seem mildly useful science.org/…/screening-against-alphafold-models-…

note that google’s thing is pattern matching, and if there’s few similar protein structures in literature, then alphafold is working on poor quality data. comments do notice a red flag or two

skillissuer, 4 days ago

if you’re using firefox, disable enhanced tracking protection to see disqus comments

skillissuer, 4 days ago

also note that the big failures come from faulty biology, not from faulty chemistry. You can set innumerable piles of cash on fire if you choose to plug a wrong enzyme

skillissuer, 4 days ago

also note it’s from january so not about the new thing

skillissuer, 4 days ago

got you

i mean specifically this one

I don’t believe this says anything useful about Alphafold or Cryo structures because I just don’t believe these hit-rates. Anyone who reports 50% success from virtual screening has something very wrong with their assay. Before doing anything they should stick a pin in the catalogue 50 times, test those compounds, and when 25 of them come back active they should stop and work out why.

The rest of criticisms is in article

skillissuer, 3 days ago (edited 3 days ago)

elaborating on that. when you can hit a protein cleanly (without some side effects (called off-target, there are also on-target side effects)) but you hit wrong protein, this doesn’t have to be a complete loss, but it’s likely. maybe you learn something, either about biology of that all or about something else that it interacts with, or maybe you have found a cure to some other disease instead. but this is the actual hard problem of drug development, especially when the biology of it all is little known. there’s a few of these drugs that started this way, fentanyl, viagra, thalidomide (as anticancer), minoxidil come to mind, and at worst you have a new tool for biologists. alphafold won’t help with that

skillissuer, 10 days ago

you have to fail intro to qm 101 and/or be stoned out of your mind to think this way

skillissuer, 10 days ago

planetary orbits are not quantized, for starters. atomic orbitals are occupied by pairs (at most) of electrons, and this is because of qm spin exists which has no analogue in large scale. electrons aren’t spinning around on an orbit, they’re more of a smudged standing wave. it’s also a staple among vapid thonkers like mckenna

skillissuer, 10 days ago

it’s not commonly discussed because it’s wrong

skillissuer, 10 days ago

these are f orbitals, there is 5 of d orbitals

skillissuer, 11 days ago

idk about manpads, but non-imaging sidewinders had reticle spinning at 100-125Hz. performance required does not imply some alien technology

skillissuer, 11 days ago

that’s for wii, imaging sensor in a missile will be much more complex and probably includes UV sensor as well (you’re not tracking a blob, but shape)

skillissuer, 10 days ago

so one in 4k or so. not terribly uncommon