The gist here is to model a genetic network as a dynamical system with two attractor states (in this case, it's leukemia and the states are apoptosis on-versus-off).
I'm looking for leads to papers that apply this type of approach to model genetic networks (not neural circuits) that have something a bit more to do with the brain; ideally not cancer.
(This is not my field). Huntington's? Fragile X? Anything neuron related?
@NicoleCRust Take a look at: Bagchee‐Clark, Ashis J., et al. "Pathway‐extended gene expression signatures integrate novel biomarkers that improve predictions of patient responses to kinase inhibitors." MedComm 1.3 (2020): 311-327.(https://onlinelibrary.wiley.com/doi/pdf/10.1002/mco2.46). We found likely attractors in pathway extended chemotherapy signatures.(and cite Kauffman): .
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