Can anyone think of a way to "quench" a HBTU/HATU/etc type coupling that doesn't involve adding water?
I've used MeOH, but I sometimes get MeOH esters which in at least one case proved to be inseparable from the desired amide product (I'm sure you know exactly how frustrating that was).
It might be possible to use <1 equiv of water with my conditions, but I'd really rather not since I directly load onto silica and do not do an aqueous work-up.
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