Researcher. You need to build out the tech tree starting early-on.
Digger. You want to unlock harder-mineral areas starting early-on.
Rancher+Farmer. Not critical to the early game, but because the combination is hard to get and Rancher requires a level of Farmer, best to get it at the start when you can pick your dupe interests.
I also start with one researcher and one digger. The third dupe kinda depends on the asteroid and what I want to focus on.
A supply/operate dupe that can be skilled towards mechatronics engineering. I typically reach the stage where I want to automate stuff with transport rails before the first dupes even have enough skillpoints to become a mechatronics engineer, so I like to start them as early as possible.
A second digger if I want to rip through the map and explore faster
Maybe a highly skilled rancher. It used to be (and maybe still is?) the case that leveling the ranching skill is very difficult. So if I know I'm gonna do a lot of ranching, I pick one of those.
Oxygen not included
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