I actually make a yearly pilgrimage of 500 miles and apart from gas stops I go nonstop, no breaks. I find that making numerous stops wears me out and I start to fall asleep in the last couple hours. Could easily be because I’m adding hours to my drive if that’s the case though.
Edit: Keep in mind though, the 250 is typically ideal. You can easily have a range down to 100 miles or less with a few years of general use. A wireless charging solution would ease such wear and tear.