Fall out of repair, and be unable to be repaired effectively without tools, resources, or knowledge that are no longer accessible?
Abso-fucking-lutely
Take a deep sea oil rig. How long do you think it’ll be operational without maintenance with all that sea water? After not too long you won’t be able to repair the damage without serious industrial capabilities, and that’s assuming you even know how to fix it.
Really even as relatively little as a few decades of total chaos and disorganization would be enough to make crawling back really hard. A century and more and it really could be impossible, or at least improbable - especially given that the humanity that comes out of the other end of the crisis is the same one that got us into it. So the remaining pieces of major valuable infrastructure left will probably get wrecked as the survivors fight over them