NicoleCRust, 7 months ago to random

Pointers to examples of using complex systems approaches to develop therapeutic interventions?

I'm excited by the type of approach presented in these three papers, which I would summarize as:

1. Model a complex system w/ attractor states (like a genetic network) with a lot of detail
2. Reduce the model's complexity to something more understandable
3. Therapy = control. Determine the intervention that will perturb the system from the unhealthy to healthy attractor state.

https://www.pnas.org/doi/full/10.1073/pnas.0806447105
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002267
https://www.nature.com/articles/ncomms11323

Do you know of any examples of this type of approach? Especially ones that led to a new type of therapy that is either approved, in clinical trials or just thought of? Maybe cancer?