The United States #Senate, in its current #toxic#senescence, offers a great deal to loathe. Its members posture and bluster and never do anything or leave; the ubiquity of the filibuster during Mitch McConnell’s time atop the institution ran it into a state of permanent brownout long before McConnell himself started powering-down like C-3PO during public appearances. Nothing works, nothing happens; as a general rule, the most action in the Senate is either when it pulls together to deliver itself of a 3000-page omnibus funding bill once per year or when one of the chamber’s many grandiose octogenarians seems notably closer to death than usual. With the filibuster’s supermajority threshold making regular business impossible, there is nothing left but a competition between variously exhausting aesthetics.
What causes pathology in #aging yeast cells? Circular DNAs (ERCs) are implicated, but @andrezylstra3@HouseleyLab &co find no impact of #ERCs on gene expression/#senescence; rather, large amplified fragments of chr XII seem responsible #PLOSBiologyhttps://plos.io/3szonvD