PLOSBiology

PLOSBiology, 1 month ago to random

New #genomics technologies and research paradigms are fueling a shift in some of the central tenets of #symbiosis.

John M Archibald @dalhousieu argues that we need to be humble and open-minded about what the data are telling us.

https://plos.io/4aLWmkZ

PLOSBiology, 1 month ago to random

Research enabled by recent technological advances has revealed that all animals and plants likely require interactions with microbes.

Margaret McFall-Ngai looks at how #symbiosis has developed as a field of research in this #PLOSBiology Perspective.

https://plos.io/4aLpHvX

PLOSBiology, 1 month ago to random

Exploring the mechanisms behind #symbiosis requires an understanding of these interactions in a range of model systems.

This #PLOSBiology Perspective discusses how the ciliate #protist Paramecium bursaria offers insights into how endosymbiotic interactions have evolved.

https://plos.io/3U6FBLO

PLOSBiology, 1 month ago to random

#Hsp70 chaperones preserve #ProteinSynthesis by promoting folding & preventing aggregation. @microbelab reports a new role of Hsp70 in #Salmonella survival during low Mg2+ conditions by binding to the #ribosome & reducing protein synthesis #PLOSBiology https://plos.io/4431K1j

PLOSBiology, 1 month ago to random

Environmental #bacteria influence many facets of #choanoflagellate biology, yet few examples of symbioses exist.

This #PLOSBiology Perspective explores how choanoflagellates can help us to understand how #symbiosis may have shaped the early evolution of animals.

https://plos.io/4cG85U5

PLOSBiology, 1 month ago to random

#ShortcutCitations: using citations instead of describing methods may compromise #reproducibility. Analysis of >800 papers shows that >90% use ≥1 shortcut citation; these significantly impair reconstruction of the original method @questBIH #PLOSBiology https://plos.io/3VI4wa0

PLOSBiology, 1 month ago to random

How do we process images with high vs low #memorability? @Blahner @Yalda_Mhz &co show that only images with high memorability scores undergo extended processing late in time throughout the ventral visual stream, including early #VisualCortex #PLOSBiology https://plos.io/4cDqn8u

PLOSBiology, 1 month ago to random

MYCN drives #neuroblastoma by activating ribo biogenesis & protein synth genes, but repressing neuronal differentiation genes. @theNCI study shows that #MYCN cooperates with the HMT G9a & WDR5 adaptor to orchestrate global gene transcription #PLOSBiology https://plos.io/4amRZ03

PLOSBiology, 1 month ago to random

#Wolbachia causes embryonic lethality in #FruitFlies by modifying #chromatin integrity in sperm. @KaurTweets @Symbionticism &co show that this occurs in the wMel-transinfected #Aedesaegypti #mosquitoes used to control vector-borne diseases #PLOSBiology https://plos.io/3xgOsBH

PLOSBiology, 1 month ago to random

Potassium channels regulate the scale of #fish fins, but how? This study shows that the scale of #zebrafish embryonic pectoral fins is determined by the regulation of intracellular K+ by retinoic acid via Rcan2 & #PotassiumChannel Kcnk5b #PLOSBiology https://plos.io/3IOCu53

PLOSBiology, 2 months ago to random

Single-organelle resolution approaches have the potential to advance our knowledge of the heterogeneity of #lysosome function.

@maxgabgut &co propose a 'lysosome states' concept that links single lysosomes to function.

#PLOSBiology #cellbiology

https://plos.io/3xatAMA

PLOSBiology, 2 months ago to random

Stem cell microenvironment: Inter-niche signaling in #Drosophila ovary reveals a mechanism involving miR124 & EGFR that regulates #StemCell function & sharpens the spatial distinction between self-renewal & differentiation microenvironments #PLOSBiology https://plos.io/3TM3Ajf

PLOSBiology, 2 months ago to random

How does E3 #ubiquitin ligase RFDW3 regulate #ReplicationFork progression & stability? This study reveals that RFWD3 ubiquitylates SMARCAL1, disengaging it from RPA, limiting its activity at stalled forks & preventing fork collapse #PLOSBiology https://plos.io/3TsE6q5

PLOSBiology, 2 months ago to climate

Coral reef #restoration faces many challenges.

@HLBurdett &co advocate for prioritizing #environmental and #climate considerations to increase the sustainability of future #CoralReefs and open up opportunities for new restoration approaches.

https://plos.io/3Pv8ui6

PLOSBiology, 2 months ago to random

#Galactose is an important sugar that can fuel glycolysis, but tracking its metabolic dynamics in vivo is challenging. @Yoo_Lab_RIKEN describe #GALDAR, a genetically encoded sensor to measure intracellular galactose dynamics in flies #PLOSBiology https://plos.io/3Vx63iO

PLOSBiology, 2 months ago to random

Sync'ing with your boss's brain: @SANPLab shows that social bonding in humans selectively increases information exchange & #prefrontal #NeuralSynchronization for human leader-follower pairs #PLOSBiology https://plos.io/49YuF8R

PLOSBiology, 2 months ago to random

How do "ghost" lineages impact use of branch length methods to infer timing of #HGT events? @toni_gabaldon &co discuss key considerations regarding the potential effect of such missing lineages: https://plos.io/4crpJLl Response by @damdevienne &co: https://plos.io/49YqVEl

PLOSBiology, 2 months ago to random

Some drugs increase the #mutation rate of their target #pathogen, raising the concerns they might increase the pathogen’s rate of adaptation. This #PLOSBiology Perspective proposes a four-step process to evaluate the evolutionary safety of new treatments.

https://plos.io/491R2sq

PLOSBiology, 2 months ago to random

The envelope protein is highly conserved among human #coronaviruses, suggesting it could be a good drug target. This #PLOSBiology study identifies iPep-SARS2-E and shows that it inhibits #SARSCoV2 infection in lung organoids and in mice.

https://plos.io/3PsLpNg

PLOSBiology, 2 months ago to random

Mismatches can induce unwanted cleavage events and off-target effects in CRISPR-Cas12a-based #GeneEditing. This #PLOSBiology study describes a high-fidelity AsCas12a variant with improved targeting specificity.

https://plos.io/48ZwhxL

PLOSBiology, 2 months ago to random

This #PLOSBiology study in E. coli reveals a novel role for polyphosphate kinase in the expression of enzymes that promote resistance to the last-resort #antibiotic polymyxin.

https://plos.io/4aewiik

PLOSBiology, 2 months ago to random

The papillae of Ciona, a marine, non-vertebrate #tunicate, have many functions crucial for their biphasic lifestyle. This #PLOSBiology study describes different papillae cell types and how they contribute to #development of the larvae.

https://plos.io/3PoXmDw

PLOSBiology, 2 months ago to random

Aging is associated with changes in #neurons thought to drive motor, sensory, and cognitive impairments. Using a Drosophila model of #aging, @Natsansor &co report that deterioration of the microtubule cytoskeleton is an important driver of neuronal aging.

https://plos.io/3IGWDKg

PLOSBiology, 2 months ago to random

The design and fabrication of customized #microwells and #microfluidic chips is often challenging. This #PLOSBiology study describes a pipeline for resin-based 3D printed constructs and provides a variety of applications in biological #experiments.

https://plos.io/3TENGHq

PLOSBiology, 2 months ago to random

PEX5 transports new proteins from cytosol to #peroxisome, where it is reversibly mono-Ub'ed at Cys11 for return to the #cytosol; longer #ubiquitin chains attached to Cys11 are rapidly removed by the enzyme E2D3, ensuring correct function #PLOSBiology https://plos.io/4a9gWf4