In terms of mental health, drugs that give any kind of relief should be treated as a shelter from the storm so you can rebuild. This means if you’re not rebuilding while you’re in shelter, your happiness is only going to last as long as your shelter is standing. Drugs wear off, and it is very easy to just want to keep putting your shelter up ad infinitum. This is where the second problem of drugs for relief comes in. The shelter is sub-standard compared to doing the things to build a lasting happiness. You can get stoned as shit, but if you and your life is still in shambles there’s only so much that can do.
All the above being said cannabis can help when you need a break. Psychedelics can help as well and microdosing incurs minimal risk. Neither of these will fix any of your problems, but they can enable you to work on your problems yourself when it was too difficult to before.
Alternatively, if you want to avoid drugs altogether meditation can be an option in some circumstances. This is barely a recommendation because meditation is a skill that you have to practice in optimal form consistently before you’ll get anything at all from it. It’s impossible to actually know whether you’re doing it right until you start to feel relief from it and so many things can make practicing mediation as a beginner almost impossible if you’re in crisis. If you attempt mediation with absolutely no expectations other than that you will fail at it until you happen to approach it in a way that works you may eventually get some relief from it. If you get it working consistently, it is far stronger than anything you can get legally without a prescription in terms of providing relief. I can give you some guidance if you’re interested in this path. Secondarily, Kava can help a little in that it dulls the pain.
Vallerian root, kanna, ashwaganda, etc. might work if you believe strongly that they’re working. Avoid depressants like alcohol because although they provide temporary relief they also make things worse when they wear off which can be a terrible cycle.