Bacteriophages are a great secondary option. Similar to how bacteria quickly evolve resistance to antibiotics, bacteriophages can quickly evolve to circumvent phage resistance.
If you spent more than 3 seconds reading what you post, you’d realize that fecal transplant only affects the gut microbiome, not body-wide resistance. Fecal transplant, obviously, does nothing to combat pneumonia, skin infections, abscesses, or literally anywhere other than the gut. As the vast majority of fatal or life threatening infections are not isolated to the gut, your argument fails. But I need not argue against citations, as the provided papers don’t even argue your point.
That’s not true. The gut microbiome regulates the entire body, including other body site’s microbiomes. This information is included in the links I shared. Here is a specific page that covers it humanmicrobiome.info/systemic/ but there’s more in the rest of the wiki as well.
What you just said is harmful misinformation and 100% demonstrates that you didn’t read a damn thing that you’re responding to and acting like you’re an expert on.
I know I’m not going to convince you, and that’s fine, but people like you get other people killed.
Steve Jobs infamously had a treatable form of cancer, but instead of going to a doctor and doing the scientifically verified treatment he ate fruit that some nut job said would cure him and he died.
The only medical advice anyone should ever give is go to a doctor. That’s it. Period. The end.
Trippling down on your pigheaded ignorance to the point where you’re now projecting all your errors and flaws outward.
Steve Jobs infamously had a treatable form of cancer, but instead of going to a doctor and doing the scientifically verified treatment he ate fruit that some nut job said would cure him and he died.
Once again, a false dichotomy, demonstrating an inability of critical thinking and ability to differentiate shades of color.
The only medical advice anyone should ever give is go to a doctor.
This would apply well to YOU, because YOU clearly have no clue what you’re talking about. Yet you violated your own policy. You should have stayed quiet on this topic which you clearly know nothing about.
You’ve linked a lot of other people’s opinions, which is fine. A lot of stuff about how doctors aren’t always right, diagnoses aren’t always correct, and how antibiotics are prescribed in situations that aren’t necessary, like viral infections, which agreed, all of that happens.
But the context you’re avoiding is your original claim.
While antibiotic resistance gets all the attention, the damage being done to our host-native microbiomes is arguably as big a threat as climate change, as the damage compounds over generations, and once it’s gone you can’t get it back. (Apr 2019).
It is beyond ridiculous and what started this whole thing.
So, again, for everyone reading, my claim is that doctors should be the ones to make medical decisions. Antibiotics save lives, and to add one more, people who advocate for their disuse because humans make mistakes, should rightfully be called out.
And since you’re such a fan of random website “sources”.
Buddy, I get it. You’re campaigning against antibiotic overuse. That’s true. Antibiotics are over prescribed. I’ve never said they weren’t.
What you need to chill on is giving people medical advice. I took a look at your post history, and this is a topic you’re clearly passionate about
But you are not a doctor. You are not even in the medical field. It looks like you’re an IT nerd. Which is great. We need nerds
But you espousing your opinions can hurt people. There are countless examples of people rejecting medicine that works, for essentially folk cures that do not. People die. Children are one of the most vulnerable to this, and I have personal experience with kids suffering because of people like you, campaigning against western medicine, convincing impressionable morons that alternative medicine works.
You are not a doctor, medical researcher, or a scientist researching bacterial diseases. You are a person reading what other people write on the Internet, and fixating on the gut biome above all other things is simply the wrong way to look at this.
My dad was allergic to practically every antibiotic. He only developed the allergy in his senior years. It was a big problem for him. Even if the antibiotic seemed to be working okay, he had to take a lot of Benadryl just in case and keep an epi pen around.
Thankfully, my mother doesn’t seem to have this problem. She’s 81, so if she hasn’t developed it yet, I don’t think she’s going to. Really sucked for my dad though.
Does this AI use the same process for piecing together things as LLMs do for art and writing? Is this a drug we have known about but not yet applied as an antibiotic or a whole new compound?
Virtual screening libraries are usually some form of expanded chemical space meaning they contain real and previously unknown compounds. The article says the 12 million compounds screened virtually were commercially available, but I couldn’t see enough of the nature paper to verify. It could be that the virtual screening set was acquired from a private company, but that doesn’t necessarily mean all the compounds are known.
llms have progressed beyond cut and paste way more than a year ago. they have shown understanding of what items are and how they behave and interact. I know it’s popular here to call it a parrot or whatever but most people don’t have access to the high level stuff and most seem afraid/snobby/parroting things themselves.
It doesn't sound like it but they don't have enough detail in the article to say.
It sounds likey they are using a classification model that takes a vectorized text representation of molecules and classifies or scores them by their expected properties/reactivity. They took 39,000 molecules with known reactivity to MRSA to train the model, I assume to classify the structures. Once trained they can feed in arbitrary molecules into the trained model and see which ones are predicted to have antibiotic properties, which they can verify with bench work.
They likely fed in molecules from classes of likely candidate structures, and the model helped focus and direct the wet work.
I'm not up on the latest, but years ago I helped a similar project using FPGAs running statistical models to direct lab work.
With a CPU or even a GPU, there is a bunch of inefficiencies for every task as they’re designed to be able to do pretty much anything - your H265 media decoder isn’t going to be doing much when you’re keeping a running sum of the number of a certain type of bond in a list of chemicals
With ASICs and a lesser extent FPGAs, you can make it so every single transistor is being used at every moment which makes them wildly efficient for doing a single repetitive task, such as running statistical analysis on a huge dataset. This is because rather than being limited by the multiprocessing ability of the CPU or GPU, you can design the “program” to run with as much multiprocessing ability as is possible based on the program, meaning if you stream one input per clock cycle, after a delay you will get one input per clock cycle out, including your update function so long as it’s simple enough (eg moving average, running sum or even just writing to memory)
This is one specific application of FPGAs (static streaming) but it’s the one that’s relevant here
So it sounds like we’re designing the instruction pipeline for maximum parallelism for our task. I was surprised to learn that the first commercial FPGAs were available as early as the '80s. I can see how this would have been an extremely effective option before CUDA became available.
This was years ago before GPU processing really took off, and we wanted the performance, but also, wanted to see if we could develop an affordable discrete lab device that could be placed in labs to aid in computationally directed bench work. So effectively, testing the efficacy of the models and designing ASICs to perform lab tests.
But it’s going to be. Until we do something to stop them, it’s absolutely going to be that way. There’s no serious view of human history that will tell you anything different.
We can’t just sit here and marvel at technology without acknowledging who controls it, who uses it, and what they’re going to use it for. Without people, AI is just a bunch of code sitting there waiting for input.
The article (and what I can access of the paper it is based on) doesn’t really give any details as to what this class is, how it works etc. All the interesting parts about this aren’t mentioned.
It sounds like they trained a classification model using 39,000 molecules with known reactivity to MRSA. The molecules are vectorized text representations of the structures. Once trained, they can run arbitrary molecules through the model and see which ones are predicted to have antibiotic properties, or at least MRSA reactivity.
They likely fed in molecules from families of structures that seem likely to contain an antibiotic but are too numerous to manually test them all. They get a prediction of which ones are likely to have the properties they want, and then start the slow process of creating and testing the molecules in the lab.
I get what they did (its been something a lot of groups have been wanting to do for years) but I am curious what molecule specifically they found that worked especially well. i.e What does this thing look like? What is the new antibiotic’s mechanism of action? None of those latter details are discussed. Its something we can only guess at.
It sounds like they are moving forward with clinical testing in partnership with a bio company, so I'm sure they withheld the information anticipating a patent. The results of this paper was the validation of the explainable AI model which identified candidate classes of compounds.
This is why we need single payer healthcare. Let them charge whatever they want, but if there is only one buyer, that buyer can also pay whatever they want.
That’s not science, that’s capitalism. Don’t forget that Dr. Jonas Salk refused to patent the polio vaccine, which is estimated to have a total value of over seven billion US dollars. Dr. Salk has always been a hero of mine.
Shit bag lawyers from the National Foundation for Infantile Paralysis later tried to see if they could patent it for themselves and luckily couldn’t. That’s capitalism for you. Fuck these guys.
Maybe things will work out for the better. Maybe they take over. Worst case scenario I blow my fucking brains out so i don’t have to live though the apocalypse.
You’re right, but We’ll get what we deserve when it comes to that.
The one thing the greedy tech bastardizers have never been able to do is shut down, not for lack of trying, the benevolent open source and human knowledge belongs to the world movements. The seven seas are still free and the most motivated thinkers are still the open source ones, matey.
They have nothing that isn’t already being extrapolated and tinkered with on private servers. If they use the soon to come AGI to make the peasant’s lives even more bleak, they might not like the damage in kind that can be done with some militant engineer’s homebrew anti-cap AGI. What could that do? Engineer a plague? Mass delete banking records? Who knows but it’s increasingly likely we’ll find out!
If wealthy “winner” humans continue to insist on making most humans live’s increasingly desperate, solely because they are never getting richer fast enough and without regard to the concept of Mutually assured destruction, then our species will have to experience the inevitable consequences of that choice. They have the capital, so its on them.
In this case I’m glad. We are close to achieving the technology to let technology self-iterate and propagate.
The direction our species chooses to apply this technology will be a reflection and measure of who we are with commensurate rewards and/or consequences.
Will some voices of sanity let us harness the power of this atom to enlighten the world? Or will we follow tradition and use our newfound power to make big boomie boom rival tribe over there, yet again?
I'm just glad I can mess around with it at home and it's not all locked up. People resisting Ai don't seem to realize it's not only here forever, but it's quickly going main stream.
Staphylococcus kills thousands of people every year, this is a good thing.
We have PLENTY of negative places you could go here on Lemmy that really really hate all things futurism and technology, please try to save your dooomerism for those places, we just literally don’t have many positive spaces left and it’s so frustrating to come from the good news of the article only to see silly comments like yours that make it seem like we are all going to die because AI found a way to help us.
Sorry, you seem to have lost the thread. We’re talking about scary things that happen movies, not current daily real-world issues which could really use our focus but we’re to involved in the media.
There is a massively conservative movement lurking in the left, which opposes any new advances and wants people to return to subsistence farming and shit. Same kind of people that argue against having kids to gut the population worldwide
Those people aren’t even worth arguing with. They’re not the people that will show up to do any work to accomplish policy objectives. They aren’t serious, their objections will never be listened to, and they don’t actually want to make anything better.
It’s just tradwife-homesteader fantasizing, just with a different economic view and less (but not 0) racism.
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