PLOSBiology

@PLOSBiology@fediscience.org

PLOS Biology is the PLOS flagship journal in the life sciences. We are a selective, open-access, not-for-profit, peer-reviewed journal aiming to help advance discovery, depressurize the publication process and drive open science

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PLOSBiology, to random

New #genomics technologies and research paradigms are fueling a shift in some of the central tenets of #symbiosis.

John M Archibald @dalhousieu argues that we need to be humble and open-minded about what the data are telling us.

https://plos.io/4aLWmkZ

PLOSBiology, to random

Research enabled by recent technological advances has revealed that all animals and plants likely require interactions with microbes.

Margaret McFall-Ngai looks at how #symbiosis has developed as a field of research in this #PLOSBiology Perspective.

https://plos.io/4aLpHvX

PLOSBiology, to random

Exploring the mechanisms behind requires an understanding of these interactions in a range of model systems.

This Perspective discusses how the ciliate Paramecium bursaria offers insights into how endosymbiotic interactions have evolved.

https://plos.io/3U6FBLO

PLOSBiology, to random

chaperones preserve by promoting folding & preventing aggregation. @microbelab reports a new role of Hsp70 in survival during low Mg2+ conditions by binding to the & reducing protein synthesis https://plos.io/4431K1j

PLOSBiology, to random

Environmental #bacteria influence many facets of #choanoflagellate biology, yet few examples of symbioses exist.

This #PLOSBiology Perspective explores how choanoflagellates can help us to understand how #symbiosis may have shaped the early evolution of animals.

https://plos.io/4cG85U5

PLOSBiology, to random

: using citations instead of describing methods may compromise . Analysis of >800 papers shows that >90% use ≥1 shortcut citation; these significantly impair reconstruction of the original method @questBIH https://plos.io/3VI4wa0

PLOSBiology, to random

How do we process images with high vs low ? @Blahner @Yalda_Mhz &co show that only images with high memorability scores undergo extended processing late in time throughout the ventral visual stream, including early https://plos.io/4cDqn8u

PLOSBiology, to random

MYCN drives by activating ribo biogenesis & protein synth genes, but repressing neuronal differentiation genes. @theNCI study shows that cooperates with the HMT G9a & WDR5 adaptor to orchestrate global gene transcription https://plos.io/4amRZ03

PLOSBiology, to random

causes embryonic lethality in by modifying integrity in sperm. @KaurTweets @Symbionticism &co show that this occurs in the wMel-transinfected used to control vector-borne diseases https://plos.io/3xgOsBH

PLOSBiology, to random

Potassium channels regulate the scale of fins, but how? This study shows that the scale of embryonic pectoral fins is determined by the regulation of intracellular K+ by retinoic acid via Rcan2 & Kcnk5b https://plos.io/3IOCu53

PLOSBiology, to random

Single-organelle resolution approaches have the potential to advance our knowledge of the heterogeneity of #lysosome function.

@maxgabgut &co propose a 'lysosome states' concept that links single lysosomes to function.

#PLOSBiology #cellbiology

https://plos.io/3xatAMA

PLOSBiology, to random

Stem cell microenvironment: Inter-niche signaling in ovary reveals a mechanism involving miR124 & EGFR that regulates function & sharpens the spatial distinction between self-renewal & differentiation microenvironments https://plos.io/3TM3Ajf

PLOSBiology, to random

How does E3 ligase RFDW3 regulate progression & stability? This study reveals that RFWD3 ubiquitylates SMARCAL1, disengaging it from RPA, limiting its activity at stalled forks & preventing fork collapse https://plos.io/3TsE6q5

PLOSBiology, to climate

Coral reef #restoration faces many challenges.

@HLBurdett &co advocate for prioritizing #environmental and #climate considerations to increase the sustainability of future #CoralReefs and open up opportunities for new restoration approaches.

https://plos.io/3Pv8ui6

PLOSBiology, to random

is an important sugar that can fuel glycolysis, but tracking its metabolic dynamics in vivo is challenging. @Yoo_Lab_RIKEN describe , a genetically encoded sensor to measure intracellular galactose dynamics in flies https://plos.io/3Vx63iO

PLOSBiology, to random

Sync'ing with your boss's brain: @SANPLab shows that social bonding in humans selectively increases information exchange & for human leader-follower pairs https://plos.io/49YuF8R

PLOSBiology, to random

How do "ghost" lineages impact use of branch length methods to infer timing of #HGT events? @toni_gabaldon &co discuss key considerations regarding the potential effect of such missing lineages: https://plos.io/4crpJLl Response by @damdevienne &co: https://plos.io/49YqVEl

PLOSBiology, to random

Some drugs increase the #mutation rate of their target #pathogen, raising the concerns they might increase the pathogen’s rate of adaptation. This #PLOSBiology Perspective proposes a four-step process to evaluate the evolutionary safety of new treatments.

https://plos.io/491R2sq

PLOSBiology, to random

The envelope protein is highly conserved among human , suggesting it could be a good drug target. This study identifies iPep-SARS2-E and shows that it inhibits infection in lung organoids and in mice.

https://plos.io/3PsLpNg

PLOSBiology, to random

Mismatches can induce unwanted cleavage events and off-target effects in CRISPR-Cas12a-based #GeneEditing. This #PLOSBiology study describes a high-fidelity AsCas12a variant with improved targeting specificity.

https://plos.io/48ZwhxL

PLOSBiology, to random

This study in E. coli reveals a novel role for polyphosphate kinase in the expression of enzymes that promote resistance to the last-resort polymyxin.

https://plos.io/4aewiik

PLOSBiology, to random

The papillae of Ciona, a marine, non-vertebrate , have many functions crucial for their biphasic lifestyle. This study describes different papillae cell types and how they contribute to of the larvae.

https://plos.io/3PoXmDw

PLOSBiology, to random

Aging is associated with changes in #neurons thought to drive motor, sensory, and cognitive impairments. Using a Drosophila model of #aging, @Natsansor &co report that deterioration of the microtubule cytoskeleton is an important driver of neuronal aging.

https://plos.io/3IGWDKg

PLOSBiology, to random

The design and fabrication of customized #microwells and #microfluidic chips is often challenging. This #PLOSBiology study describes a pipeline for resin-based 3D printed constructs and provides a variety of applications in biological #experiments.

https://plos.io/3TENGHq

PLOSBiology, to random

PEX5 transports new proteins from cytosol to , where it is reversibly mono-Ub'ed at Cys11 for return to the ; longer chains attached to Cys11 are rapidly removed by the enzyme E2D3, ensuring correct function https://plos.io/4a9gWf4

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