For those curious how efficient these things are, recently I did some tests using this tool (clear your cache between tests).
I had decided to install an additional DNS blocker on my OpenWRT router so I was curious how these methods stack up against each other.
I tested uBlock Origin (default lists, reports 116k network filters), the Firefox (122) built-in ETP (Enhanced Tracking Protection) and the router adblock (only a modest 65k IPs in the default set, you can add more lists).
Everything off gives me a score of only 3% blocked. Those 3% must be stuff so outrageous that they probably get blocked by upstream DNS servers.