@elduvelle_neuro@neuromatch.social
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elduvelle_neuro

@elduvelle_neuro@neuromatch.social

#Neuroscientist, postdoctoral researcher studying spatial memory and flexible decision-making with #Tetrode recordings in the #Hippocampus of rats solving complex spatial tasks. This is my #Neuroscience focused account.

Will follow only active accounts to avoid “ghosts”. Please answer my pinned post!

(profile pic shows a Long-Evans rat with his paw on an old-school compass. photo by R. Grieves; header shows raw hippocampal neural activity recorded from a resting rat, with #Ripples and associated spiking)

This profile is from a federated server and may be incomplete. Browse more on the original instance.

elduvelle_neuro, to random
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Welcome to all! ❤️​🐀​
Potential new followers: can we try something out?

  • if you're a (of any status, yes, undergraduate students can be neuroscientists), could you answer with your neuro 'categories': Experimentalist, Computational, Philosopher, Fly, Human, Rodent, Whale, Tetrodes, Calcium imaging, fMRI, EEG, etc. This is so that I (and possibly others) can put you in a List! I'll share my lists once they have grown enough 😀​

  • if you're not a Neuroscientist, this account will probably not follow you, but you are totally free to follow it, and also to tell us about you and any questions you might have about neuroscience!

  • if you want to learn about neuroscience, I will try to post beginner-level explanations with the hashtag . Just an experiment...

elduvelle_neuro, to Neuroscience
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What is the difference between Behavioural and ? 🧠

elduvelle_neuro, to random
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Way too many interesting posters to put in my meeting planner! 🤩 🤯

https://www.abstractsonline.com/pp8/#!/10892
(This is just a link to the planner, it would be great if we could share our own ones, but I’m not sure that’s possible)

aheadofthenerve, to random
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as long as I have the attenion of the HPC folks-- what are we doing these days when bootstrapping for place cell mutual info? shuffling positions and keeping spike times (and thus ISI) constant, or shuffling spike times? Seen both in papers and unsure if there is a consensus

elduvelle_neuro,
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@aheadofthenerve I would say shuffle the spike trains (so not randomly shuffle the times of spikes but shift them all of the same amount for each shuffle to maintain firing statistics but disrupt the relation of the firing with location). Also I would make sure to use high within-session stability as an additional criterion for place cells. Looking forward to a sneak peek of your data :)

elduvelle_neuro,
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@aheadofthenerve I don’t recall seeing position shuffling or even shifting for characterization of place cells but maybe that’s for calcium imaging when you don’t have access to spike? I would say the standard is what I said above for ephys data. Shuffling position seems bad. Shifting position seems like it should be exactly the same as shifting times no?

elduvelle_neuro, to random
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Any chance someone could summarize the “IIT as pseudoscience” debate? Starting with the basics like what is IIT…

elduvelle_neuro, to Neuroscience
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Here are a few of my favourites from my twitter-detached archive :

1- Types of papers...

https://elduvelle.github.io/ElDuvelle/status/1388075267453857792/

1/x

elduvelle_neuro, to random
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What do who record raw data from many channels (, …) do for data backup and storage? I just bought 2 x 4Tb external drives and it looks like they won’t be enough (at all). Is there a cheap and reliable AND huge storage way to do this?

elduvelle_neuro,
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@jonny thank you! It’s great that you have some doc for it! I’ll be helping set up a new lab soon and this might come in handy - I’ll probably ask you more about this in a few months.
My current lab already has a NAS I think but at the moment I’m looking for a backup for that as none of my computers have enough storage to hold all the data at once and I don’t really like having it just in one place, even if that’s on a RAID system

elduvelle_neuro, to random
@elduvelle_neuro@neuromatch.social avatar

The last ’ll be building here in the US!
(I’m leaving my current postdoc in 6 weeks to go on holidays and then maybe another postdoc in Glasgow!)

elduvelle_neuro,
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@NicoleCRust thank you Nicole! ☺️

elduvelle_neuro, to random
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Ok maybe this is the best cluster space ever
(also, from an implant that’s almost 4 months old!)

elduvelle_neuro,
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@jonny yes I counted 10+. My current algo will only find the clearly separated ones. Probably with Klustakwick you could get 15 or so..

elduvelle_neuro, to random
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Best time and place to realize that you don’t have access to your animal unit past midnight is definitely not at 12:05 AM, in front of the animal unit, with a rat 🙃

elduvelle_neuro,
@elduvelle_neuro@neuromatch.social avatar

@jonny I don’t know why I’m just seeing this, but yes… fortunately I have “night” access now, not that I would like to test it again

elduvelle_neuro, to random
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What’s your best guide on extracellular recordings shapes to know if you’re recording from soma, axon, dendrite etc.? (Most interested about of course)

elduvelle_neuro,
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@jonny supposedly, as shown in this paper ⬇️ but I wonder if there is something a bit more clear-cut…
Generally when I see a symmetrical (mexican hat) waveform I consider it’s an axon / fiber, and large interneuron or pyramidal waveforms are clearly from the cell body but it’s all quite handwavy…

On the Origin of the Extracellular Action Potential Waveform: A Modeling Study

elduvelle_neuro, to random
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poll: which is your favourite manual (refinement) program?🧠🖥️

Polls don’t have enough options so detailed answers would be great 😃:

1: Klusters
2: Mclust
3: Offline Sorter
4: Phy
5: Spike Sort 3D
6: Tint (I didn't find a link describing the software)
7: Other
8: None (all automatised!)

(Note: I asked the same poll on the NeuroMethods SpikeSorting channel)

elduvelle_neuro, to random
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Some interesting things to check out this morning…

image/jpeg
image/jpeg

elduvelle_neuro, to Neuroscience
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question:

What is the smallest optimal distance between independent in dorsal CA1 (so that you don’t record from the same neuron in adjacent tetrodes and also movement of one doesn’t influence the movement of others)?
Say, using 12.7 μm diameter wire?

elduvelle_neuro, to random
@elduvelle_neuro@neuromatch.social avatar

Here’s a podcast on that seems very interesting, in French:

https://www.radiofrance.fr/franceculture/podcasts/serie-la-fabrique-des-souvenirs

“Une série spéciale sur la fabrique des souvenirs🎄:
Comment s'impriment-ils dans le cerveau ?
Qu'est-ce que la mémoire collective ?
Les poissons ont-ils vraiment mauvaise mémoire ?
Que sont les faux-souvenirs ?
Comment soigner les trauma ?”

By Alexandra Delbot (not on Masto?)
With contributions from @alexandra_gros

elduvelle_neuro, to random
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I bet you’ve never seen a bigger… cluster than my one 😁
(Well, technically, my ’s)

elduvelle_neuro, to random
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is really intense 😳

elduvelle_neuro, to academia
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Are there any grants that you can apply to at the stage to do data analysis?

elduvelle_neuro, to random
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Best sounds for falling asleep?
Tired: sounds of rain 🌧️
Wired: sounds of rat brain 🧠
Inspired: sounds of sleeping rat brain 💤

Edit: re-added alt text which had disappeared for some reason

Video of a neural recoding from a sleeping / falling asleep rat, showing the activity from 96 channels in dorsal hippocampus. The burst-like sounds are ripples, events that involve the reactivation of many hippocampal neurons during a short amount of time and thought to support memory consolidation.

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