@elduvelle_neuro@neuromatch.social
@elduvelle_neuro@neuromatch.social avatar

elduvelle_neuro

@elduvelle_neuro@neuromatch.social

#Neuroscientist, postdoctoral researcher studying spatial memory and flexible decision-making with #Tetrode recordings in the #Hippocampus of rats solving complex spatial tasks. This is my #Neuroscience focused account.

Will follow only active accounts to avoid “ghosts”. Please answer my pinned post!

(profile pic shows a Long-Evans rat with his paw on an old-school compass. photo by R. Grieves; header shows raw hippocampal neural activity recorded from a resting rat, with #Ripples and associated spiking)

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elduvelle_neuro, to Neuroscience
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of my -oriented account! 🧠​

I am a postdoctoral researcher investigating 🐀​ doing flexible 🗺️​ and how their might support this fascinating ability.
Is it ?
Is it ?
​Is it ?
Is it everything, everywhere (... yes, yes, all at once)?

This account will post, boost and follow specifically neuroscience content, don't hesitate to tag it when relevant.

Followers, please tell us about yourself under my pinned tweet!

elduvelle_neuro, to random
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Hi all! My first "neuro-focused" post 🧠​ has to be these beautiful that I recorded in a foraging for cocops in a rectangle.

⏬​(trying this out)

What are "place cells"? They are a category of neurons, first discovered in the brain of rats, that activate only in specific locations in a given environment. Each place cell fires at a different location, together forming a sort of map () of all the locations that we know.

plot legend is described in the alt-text

This screenshot show similar data as the other plot, but speed-filtered (only data when the rat was moving and not resting) and in the form of a rate map, where high firing rate (spikes / second) in a given location is shown as red and low firing is shown as blue. Note how each cell has its own specific region of high-firing with a variety of sizes and shapes and locations of that region (called the 'place field').

elduvelle_neuro, to academia
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Are there any grants that you can apply to at the stage to do data analysis?

elduvelle_neuro, to Neuroscience
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Abstract submission for the conference is now open!

https://www.cosyne.org/abstracts-submission
where: Lisbon and Cascais, Portugal
when: 29 February to 5 March 2024

double-blind reviewing process 👍

Are you going?

elduvelle_neuro, to Neuroscience
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Here are a few of my favourites from my twitter-detached archive :

1- Types of papers...

https://elduvelle.github.io/ElDuvelle/status/1388075267453857792/

1/x

elduvelle_neuro, to random
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The coolest experiments you’ll see all year in the field… and I’m not saying this lightly! Congrats to all authors!

Btw they are at in the same session as me (here)! 👀👀👀

From: @PhiloNeuroScie
https://neuromatch.social/@PhiloNeuroScie/111364100508297145

elduvelle_neuro, to Neuroscience
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Closing application date coming soon (Oct 30th) for this 3-year position in the lab of @katejjeffery, now in Glasgow!

“on the neural processing of space and direction in freely behaving rodents”

https://www.nature.com/naturecareers/job/12804781/research-associate/

elduvelle_neuro, to random
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This new review from has got to be good! Finally, some attention is given to ❤️🧠

The role of the hippocampus in the consolidation of emotional memories during sleep

elduvelle_neuro, to random
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I will be presenting this poster on tomorrow (Wed 15th Nov) at !

I'm also uploading the poster as an image here, and it's on the SFN website: https://cattendee.abstractsonline.com/meeting/10892/presentation/33535
you can ask questions in the chat there (I'll check it regularly as long as the poster is up, but probably not tomorrow). Little summary below:

Our goal was to investigate if replay of hippocampal was indeed reflecting immediate .

The existing literature is a little unclear: some studies find 'planning replay' and some do not. Most of the time, planning is not dissociated from reward consumption in these studies as they can generally be simplified to an alternation between two rewarded locations. In our case, we separate the location of planning from the location of reward and focus on replay happening at the planning time.

At the location of planning, we find that:

  1. there is actually almost no replay at the time of planning
  2. the rare 'start replay' events do NOT over-represent the future trajectory, or even the goal
  3. the rare 'start replay' events do not differ for successful vs unsuccessful planning.

At the goal location, we find that:

  1. Many replays occur at the goal, even before the reward delivery!
  2. 'goal replays' strongly over-represent the goal (either before or after reward delivery)
  3. 'goal replays' do not over-represent the current trajectory compared to the alternative trajectory, or even the optimal path if the less-optimal path was taken
  4. 'goal replays' were strongly affected by errors and were quasi-absent during error trials (choosing an unrewarded end box)

In conclusion:

Reward (received or expected), but not planning, drives hippocampal replay!

Let me know if you have any questions after looking at the poster :D

elduvelle_neuro, to random
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What’s your best guide on extracellular recordings shapes to know if you’re recording from soma, axon, dendrite etc.? (Most interested about of course)

elduvelle_neuro, to random
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Best sounds for falling asleep?
Tired: sounds of rain 🌧️
Wired: sounds of rat brain 🧠
Inspired: sounds of sleeping rat brain 💤

Edit: re-added alt text which had disappeared for some reason

Video of a neural recoding from a sleeping / falling asleep rat, showing the activity from 96 channels in dorsal hippocampus. The burst-like sounds are ripples, events that involve the reactivation of many hippocampal neurons during a short amount of time and thought to support memory consolidation.

elduvelle_neuro, to random
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The application deadline has been extended for this conference to Oct 22:
Bridging Diverse Perspectives on the Mechanistic Basis of Foraging
Date: February 25 - 28, 2024
Where: I’m guessing Janelia Research Campus, Ashburn, Virginia, USA

No fees. Hotel + meals covered. Travel support available!

elduvelle_neuro, to Neuroscience
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Check out this thread about phase-dependent excitability in the ! Really exciting (😁) work by my colleague @manishm in the ⬇️

From: @manishm
https://neuromatch.social/@manishm/111865248137896127

elduvelle_neuro, to Neuroscience
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question:

What is the smallest optimal distance between independent in dorsal CA1 (so that you don’t record from the same neuron in adjacent tetrodes and also movement of one doesn’t influence the movement of others)?
Say, using 12.7 μm diameter wire?

elduvelle_neuro, to Neuroscience
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Tenure-track position at the Assistant Professor level, in the Department of Psychological & Brain Sciences at Boston University (yes that’s where is!)
“computational neuroscience, computational cognitive neuroscience, or machine learning/data science approaches to understanding brain and cognition”
https://academicjobsonline.org/ajo/jobs/25527
Deadline to apply: Nov 15th 2023

elduvelle_neuro, to Neuroscience
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I’ll be presenting a poster about at !

The session: https://www.abstractsonline.com/pp8/#!/10892/session/1900

The poster: Hippocampal replay does not reflect trajectory planning in a spatial planning task

The date: November 15, 2023, 8:00 AM - 12:00 PM

The location: Walter E. Washington Convention center, Washington D.C., WCC Halls A-C

Will you be there?!? There is also an online version!

Teaser video ⬇️

1/2

Matlab-generated video of Bayesian decoding of a replay event in the Hexamaze, the green circle is the rat’s position (here, at the goal), the red cross is the position of maximum decoded probability for each time-window during the replay event

elduvelle_neuro, to Nostalgia
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That’s a great question! Do we know anything about the neural bases of ?

From: @sashin
https://mastodon.online/@sashin/111656749348172778

elduvelle_neuro, to random
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This looks super interesting!!

From: @biorxiv_neursci
https://biologists.social/

elduvelle_neuro, to random
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I think it’s been around for a while but here’s a great primer / tutorial on techniques and basic notions, from :

https://oe-ephys-course.readthedocs.io/en/latest/EEA/theoryday1.html

elduvelle_neuro, to random
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I know we just finished but who’s coming to ? The abstract submission deadline is coming very soon!!

From: @CosyneMeeting
https://neuromatch.social/@CosyneMeeting/111426958317157928

elduvelle_neuro, to random
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Seen on twitter, from :

“One month left to submit abstracts for the hippocampus green meeting
http://hippocampusgreen.net/wp/
Join us for this 2-day conference focusing on hippocampal physiology, network dynamics, and the phenomenon of replay in freely behaving animal models (London, June 10-11, 2024)”

Looks pretty cool! If only I could plan my life that far in advance 😅

elduvelle_neuro, to random
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In discussions I realized people can have very different definitions of “planning”.

Can we try an experiment? Without looking it up (answers to this post included), can you write down the first definition of “planning” that comes to mind, and then write down your research specialty (if you are a researcher) at the end? There are no wrong answers and anyone can contribute! 🙏

⬇️🧠💭

elduvelle_neuro, to random
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What do who record raw data from many channels (, …) do for data backup and storage? I just bought 2 x 4Tb external drives and it looks like they won’t be enough (at all). Is there a cheap and reliable AND huge storage way to do this?

elduvelle_neuro, to random
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Warm welcome to John, expert in large-scale recordings and cool analyses of neural data! 🐀🧠

From: @johnwidloski
https://neuromatch.social/@johnwidloski/111110213834938123

elduvelle_neuro, to random
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poll: which is your favourite manual (refinement) program?🧠🖥️

Polls don’t have enough options so detailed answers would be great 😃:

1: Klusters
2: Mclust
3: Offline Sorter
4: Phy
5: Spike Sort 3D
6: Tint (I didn't find a link describing the software)
7: Other
8: None (all automatised!)

(Note: I asked the same poll on the NeuroMethods SpikeSorting channel)

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