jekely, to Neuroscience
@jekely@biologists.social avatar

We have now published a new and massively extended/reworked preprint of the whole-body larval with over 50 figures

https://www.biorxiv.org/content/10.1101/2024.03.17.585258v1

All the analyses, plots and figures should be reproducible in with the code provided:

https://zenodo.org/doi/10.5281/zenodo.10825370

@zenodo_org

by querying our public database:

https://catmaid.jekelylab.ex.ac.uk

@biology
@biorxivpreprint

albertcardona, to random
@albertcardona@mathstodon.xyz avatar

Our work made it into the "7 medical breakthroughs that gave us hope in 2023" of – proud! They even chose our image of the larval brain neurons for the header:

https://www.nationalgeographic.com/premium/article/medical-breakthroughs-2023-gene-therapy-crispr-cancer-fertility

albertcardona,
@albertcardona@mathstodon.xyz avatar

@steveroyle

Thanks! The image was made in Blender using a python framework that accesses the reconstructed neurons directly from the database using a REST API: https://github.com/schlegelp/CATMAID-to-Blender

You can do it too by pulling the data from the Virtual Fly Brain database. The larval brain is at:

https://l1em.catmaid.virtualflybrain.org/?pid=1&zp=108250&yp=82961.59999999999&xp=54210.799999999996&tool=tracingtool&sid0=1&s0=2.4999999999999996&help=true&layout=h(XY,%20%7B%20type:%20%22neuron-search%22,%20id:%20%22neuron-search-1%22,%20options:%20%7B%22annotation-name%22:%20%22papers%22%7D%7D,%200.6

... and its REST API can be seen simply by adding /apis/ to the URL:

https://l1em.catmaid.virtualflybrain.org/apis/

Darkstar2016, to Fursuit
@Darkstar2016@socel.net avatar
albertcardona, to Neuroscience
@albertcardona@mathstodon.xyz avatar

A connectome of the optic lobe of the extremely tiny fairy wasp, Megaphragma sp.

"A complete reconstruction of the early visual system of an adult insect", by Chua et al. 2023 (Chklovskii & Polilov) https://www.sciencedirect.com/science/article/pii/S096098222301237X

Don't miss the supplemental figures.

"Compared with the honeybee and the fruit fly, Megaphragma exhibits the following miniaturization-related adaptations: a significant reduction in the number of ommatidia, absence of several cell types, reduced size, and denucleation of neurons. Interestingly, the reduction in lens diameter is less than that expected from the optimization of the optical resolution of the eye. This suggests that light sensitivity is a more important
consideration when lens diameter approaches the wavelength of light. The absence of wide-field (or non-columnar) lamina neurons in Megaphragma could be a consequence of the smaller number of ommatidia, their larger acceptance angle, and the lower resolving power of the eye."

Volume assembled with and , and its neurons and synapses mapped with . Woohoo!

albertcardona, to random
@albertcardona@mathstodon.xyz avatar

Today the peer-reviewed version of our preprint is out:

"The of an insect brain"
https://www.science.org/doi/10.1126/science.add9330

Congrats to co-first authors Michael Winding and Benjamin Pedigo, and to all our lab members and collaborators who made this work possible over the years. A journey that started over 10 years ago–and yet this is but a new beginning. So much more to come.

See my on the preprint from back in the Autumn: https://mathstodon.xyz/@albertcardona/109422190525090990

The data is available both as supplements and directly via thanks to hosting by the :
https://l1em.catmaid.virtualflybrain.org/?pid=1&zp=108250&yp=82961.59999999999&xp=54210.799999999996&tool=tracingtool&sid0=1&s0=2.4999999999999996&help=true&layout=h(XY,%20%7B%20type:%20%22neuron-search%22,%20id:%20%22neuron-search-1%22,%20options:%20%7B%22annotation-name%22:%20%22papers%22%7D%7D,%200.6

(The "Winding, Pedigo et al. 2023" annotation listing all included neurons will appear very soon in an upcoming update.)

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