@elduvelle_neuro@neuromatch.social
@elduvelle_neuro@neuromatch.social avatar

elduvelle_neuro

@elduvelle_neuro@neuromatch.social

#Neuroscientist, postdoctoral researcher studying spatial memory and flexible decision-making with #Tetrode recordings in the #Hippocampus of rats solving complex spatial tasks. This is my #Neuroscience focused account.

Will follow only active accounts to avoid “ghosts”. Please answer my pinned post!

(profile pic shows a Long-Evans rat with his paw on an old-school compass. photo by R. Grieves; header shows raw hippocampal neural activity recorded from a resting rat, with #Ripples and associated spiking)

This profile is from a federated server and may be incomplete. Browse more on the original instance.

elduvelle_neuro, to random
@elduvelle_neuro@neuromatch.social avatar

What do who record raw data from many channels (, …) do for data backup and storage? I just bought 2 x 4Tb external drives and it looks like they won’t be enough (at all). Is there a cheap and reliable AND huge storage way to do this?

elduvelle_neuro, to random
@elduvelle_neuro@neuromatch.social avatar

I bet you’ve never seen a bigger… cluster than my one 😁
(Well, technically, my ’s)

elduvelle_neuro, to random
@elduvelle_neuro@neuromatch.social avatar

Best time and place to realize that you don’t have access to your animal unit past midnight is definitely not at 12:05 AM, in front of the animal unit, with a rat 🙃

elduvelle_neuro, to random
@elduvelle_neuro@neuromatch.social avatar

What’s your best guide on extracellular recordings shapes to know if you’re recording from soma, axon, dendrite etc.? (Most interested about of course)

elduvelle_neuro,
@elduvelle_neuro@neuromatch.social avatar

@jonny supposedly, as shown in this paper ⬇️ but I wonder if there is something a bit more clear-cut…
Generally when I see a symmetrical (mexican hat) waveform I consider it’s an axon / fiber, and large interneuron or pyramidal waveforms are clearly from the cell body but it’s all quite handwavy…

On the Origin of the Extracellular Action Potential Waveform: A Modeling Study

elduvelle_neuro, to random
@elduvelle_neuro@neuromatch.social avatar

Best sounds for falling asleep?
Tired: sounds of rain 🌧️
Wired: sounds of rat brain 🧠
Inspired: sounds of sleeping rat brain 💤

Edit: re-added alt text which had disappeared for some reason

Video of a neural recoding from a sleeping / falling asleep rat, showing the activity from 96 channels in dorsal hippocampus. The burst-like sounds are ripples, events that involve the reactivation of many hippocampal neurons during a short amount of time and thought to support memory consolidation.

elduvelle_neuro, to random
@elduvelle_neuro@neuromatch.social avatar

The last ’ll be building here in the US!
(I’m leaving my current postdoc in 6 weeks to go on holidays and then maybe another postdoc in Glasgow!)

elduvelle_neuro,
@elduvelle_neuro@neuromatch.social avatar

@NicoleCRust thank you Nicole! ☺️

aheadofthenerve, to random
@aheadofthenerve@neuromatch.social avatar

as long as I have the attenion of the HPC folks-- what are we doing these days when bootstrapping for place cell mutual info? shuffling positions and keeping spike times (and thus ISI) constant, or shuffling spike times? Seen both in papers and unsure if there is a consensus

elduvelle_neuro,
@elduvelle_neuro@neuromatch.social avatar

@aheadofthenerve I would say shuffle the spike trains (so not randomly shuffle the times of spikes but shift them all of the same amount for each shuffle to maintain firing statistics but disrupt the relation of the firing with location). Also I would make sure to use high within-session stability as an additional criterion for place cells. Looking forward to a sneak peek of your data :)

elduvelle_neuro,
@elduvelle_neuro@neuromatch.social avatar

@aheadofthenerve I don’t recall seeing position shuffling or even shifting for characterization of place cells but maybe that’s for calcium imaging when you don’t have access to spike? I would say the standard is what I said above for ephys data. Shuffling position seems bad. Shifting position seems like it should be exactly the same as shifting times no?

elduvelle_neuro, to Neuroscience
@elduvelle_neuro@neuromatch.social avatar

question:

What is the smallest optimal distance between independent in dorsal CA1 (so that you don’t record from the same neuron in adjacent tetrodes and also movement of one doesn’t influence the movement of others)?
Say, using 12.7 μm diameter wire?

elduvelle_neuro,
@elduvelle_neuro@neuromatch.social avatar

@jonny @chrisXrodgers haha indeed he’s been helping with that same question on the NeuroMethods slack!

I have to say, now that I’ve tried the single-tetrode with small (12.7 microns) nichrome wire, using precise shuttles (metal, not 3D printed), the movements are surprisingly responsive! Sure, the brain is jello, but these tetrodes are quite stiff, so they seem to move well (as far as I can see from looking at and listening to the signals, at least).

elduvelle_neuro, to Neuroscience
@elduvelle_neuro@neuromatch.social avatar

Check out this thread about phase-dependent excitability in the ! Really exciting (😁) work by my colleague @manishm in the ⬇️

From: @manishm
https://neuromatch.social/@manishm/111865248137896127

aheadofthenerve, to random
@aheadofthenerve@neuromatch.social avatar

new sleep box! also spilled coffee all over myself!

image/png

elduvelle_neuro,
@elduvelle_neuro@neuromatch.social avatar

@jonny @aheadofthenerve it took me a while to find the best sleep box but I ended up using an empty cage with some cloth towels and paper towels.. worked pretty well, and easy to clean!
This was an earlier prototype:

aheadofthenerve, to random
@aheadofthenerve@neuromatch.social avatar

Ok... I'm here I guess. Any tools for finding folks I follow on twitter?

elduvelle_neuro,
@elduvelle_neuro@neuromatch.social avatar

@aheadofthenerve Hiiiiiii 😃 So glad to see you on here!!

There used to be tools for that but I don’t know it they still work, I’m sure others will have more insights.

To find Neuro people, you can look at the accounts I follow with this account, or check out the or hashtag.

Also, the best thing is usually to write an # Introduction post (with the actual hashtag) telling people a bit about you and your interests and what you plan to post about - then check out who’s boosting it or following you and you can follow them if you want.

Let us know if you have any questions! And Welcome! 🤗

elduvelle_neuro,
@elduvelle_neuro@neuromatch.social avatar

@aheadofthenerve Hope you’ll bring all your still-on-twitter friends on here!

Also, our instance (neuromatch.social) and many others have defederated from Threads (for many reasons, among which their transphobic content which is against our rules). If they fix it we might eventually connect back…

elduvelle_neuro,
@elduvelle_neuro@neuromatch.social avatar

@jonny Yes! But someone improved the formatting, it looks much cleaner now than when I wrote it 😅
You’re right, I could add a “special neuroscientists” paragraph!

@aheadofthenerve

kevinbolding, to Neuroscience
@kevinbolding@neuromatch.social avatar

What do we think are “open science” venues for short reviews in neuroscience?

elduvelle_neuro,
@elduvelle_neuro@neuromatch.social avatar

@kevinbolding by “open science” do you mean open access?
And how short are we talking about?
What about @eLife ?

neuralreckoning, to philosophy
@neuralreckoning@neuromatch.social avatar

question from someone who read stuff on this years ago but nothing from . Is it generally understood to be a memory phenomenon? It seems logically that it must be (see below), but that's not the way the philosophy stuff I have read about it discussed it.

My argument is that the only thing we could be talking about if we're talking consciousness is things that have made their way into a specific memory subsystem (the ones that are accessible to our language systems), otherwise we wouldn't be able to talk about it. Similarly, anything that has made its way into that memory subsystem would also be something we were conscious of. In other words, consciousness is just the set of things that go into that subsystem.

So is consciousness just the study of some particular memory subsystem and the way it interacts with other systems like language? And if we don't understand how memory works, can we understand anything about consciousness?

elduvelle_neuro,
@elduvelle_neuro@neuromatch.social avatar

@neuralreckoning not an expert but isn’t consciousness also about immediate sensations and not just memorized events? Like, I get hurt by something, I am then conscious of the pain, or even if I’m staying immobile doing nothing and trying to think of nothing.. I am conscious of breathing and sitting on the couch?

For me consciousness is just the neural activations happening in your brain that are coherent enough that they pass a threshold for you to be aware of it. Sensation, memory, action, could be anything…

elduvelle_neuro, to random
@elduvelle_neuro@neuromatch.social avatar

Here’s a podcast on that seems very interesting, in French:

https://www.radiofrance.fr/franceculture/podcasts/serie-la-fabrique-des-souvenirs

“Une série spéciale sur la fabrique des souvenirs🎄:
Comment s'impriment-ils dans le cerveau ?
Qu'est-ce que la mémoire collective ?
Les poissons ont-ils vraiment mauvaise mémoire ?
Que sont les faux-souvenirs ?
Comment soigner les trauma ?”

By Alexandra Delbot (not on Masto?)
With contributions from @alexandra_gros

elduvelle_neuro, to Nostalgia
@elduvelle_neuro@neuromatch.social avatar

That’s a great question! Do we know anything about the neural bases of ?

From: @sashin
https://mastodon.online/@sashin/111656749348172778

elduvelle_neuro, to random
@elduvelle_neuro@neuromatch.social avatar

I think it’s been around for a while but here’s a great primer / tutorial on techniques and basic notions, from :

https://oe-ephys-course.readthedocs.io/en/latest/EEA/theoryday1.html

elduvelle_neuro, to random
@elduvelle_neuro@neuromatch.social avatar

Seen on twitter, from :

“One month left to submit abstracts for the hippocampus green meeting
http://hippocampusgreen.net/wp/
Join us for this 2-day conference focusing on hippocampal physiology, network dynamics, and the phenomenon of replay in freely behaving animal models (London, June 10-11, 2024)”

Looks pretty cool! If only I could plan my life that far in advance 😅

elduvelle_neuro, to random
@elduvelle_neuro@neuromatch.social avatar

In discussions I realized people can have very different definitions of “planning”.

Can we try an experiment? Without looking it up (answers to this post included), can you write down the first definition of “planning” that comes to mind, and then write down your research specialty (if you are a researcher) at the end? There are no wrong answers and anyone can contribute! 🙏

⬇️🧠💭

albertcardona, to Neuroscience
@albertcardona@mathstodon.xyz avatar

Periodic reminder of what fMRI's BOLD signal is measuring, and its temporal dynamics:

"blood oxygenation level–dependent (BOLD) contrast. [...] increased signal in a voxel measured with an EPI [echo planar imaging] sequence indicates recent neuronal activity because of the relative increase in local blood oxygenation that accompanies such activity. The temporal profile of this BOLD response, known as the hemodynamic response function, looks like a bell curve with a long tail, peaking around 4 to 5 seconds after local neural activity and returning to baseline after 12 to 15 seconds."

From "Principles of Neural Science", Kandel et al. 6th edition, page 115.

No matter how fast the EPI imaging is (~100 ms), the BOLD dynamics makes GCaMP look lighting fast. Temporally deconvolving BOLD is possible, to a point, but remember its spatial resolution is measured in millimetres, whereas neuronal somas measure ~0.025 millimetres.

elduvelle_neuro,
@elduvelle_neuro@neuromatch.social avatar

@albertcardona Doesn’t it also indicate activity of other brain cells like glia and astrocytes?

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