@xtaldave@xtaldave.net
@xtaldave@xtaldave.net avatar

xtaldave

@xtaldave@xtaldave.net

Your friendly neighbourhood macromolecular crystallographer. Working on treatments for Cancer & Neurodegeneration.

Mediocre lefty bassist.
Fairphone Enjoyer.
Xennial.
Mostly in and around London, UK.

Born at 335 ppm. Go 💚 or go 🪦

May contain traces of hyperbole & sarcasm.

Alt Profile: Street art of Donald Duck, dressed as Satan
Alt Banner: A glowing blue drug molecule bound to RET kinase domain

#Science #StructuralBiology #Crystallography #Bass #Mastodog #London #nobot

This profile is from a federated server and may be incomplete. Browse more on the original instance.

xtaldave, to random
@xtaldave@xtaldave.net avatar

Cuuuuuuuuuuuuuunts

Let's be clear, there is no confusion, just bigotry. They want to legally enshrine bigotry.

BBC News - Tories pledge to tackle 'confusion' over legal definition of sex
https://www.bbc.com/news/articles/c0kkvkkejgno

xtaldave, to random
@xtaldave@xtaldave.net avatar

If Labour wins a 1945-style landslide, it will have no excuse for playing it safe | Larry Elliott | The Guardian

Yes yes and yes. A massive mandate requires a bold program. PR. Renationalisation of key infrastructure. Wealth taxes. All that good shit.

https://www.theguardian.com/commentisfree/article/2024/may/30/labour-1945-tories-fiscal-rules-election

xtaldave, to random
@xtaldave@xtaldave.net avatar

Who knew Varadkar was such an absolute UNIT?

xtaldave, to random
@xtaldave@xtaldave.net avatar

"UK is 'running out of ghosts' as old spirits dying off, paranormal expert says"

xtaldave, to random
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Labour's Rachel Reeves rules out increasing income tax or NI

What is the actual point of this? We know the country is on its knees. We need to invest. I'd gladly pay more taxes to have functional NHS, roads, schools, etc.

https://www.bbc.co.uk/news/uk-politics-69063581

xtaldave, to random
@xtaldave@xtaldave.net avatar

Mechanical-Armed Grimes Flees Elon Musk Compound With Five Wives In Stolen Cybertruck

"...escape to the idyllic, faraway land of Grimes’ childhood, which she simply called “Canada.”"

https://www.theonion.com/mechanical-armed-grimes-flees-elon-musk-compound-with-f-1851488909

xtaldave, to random
@xtaldave@xtaldave.net avatar

Happy Towel Day, Hoopy Froods!

Flashing Don't Panic GIF

xtaldave, to random
@xtaldave@xtaldave.net avatar

Oh bollocks.

Microplastics found in every human testicle in study | Plastics | The Guardian

https://www.theguardian.com/environment/article/2024/may/20/microplastics-human-testicles-study-sperm-counts

xtaldave, to random
@xtaldave@xtaldave.net avatar

Putin denies plans to capture Ukrainian city of Kharkiv

So he definitely does then. 👀

https://www.channel4.com/news/putin-denies-plans-to-capture-ukrainian-city-of-kharkiv

xtaldave, to bass
@xtaldave@xtaldave.net avatar

This bass has an Ass. (It's a Caracal 034)

xtaldave, to strucbio
@xtaldave@xtaldave.net avatar

:geordi_no: Alphafold3. Not FOSS. Not FAIR. Public version has important features redacted.

:geordi_ye: OpenFold: retraining AlphaFold2 yields new insights into its learning mechanisms and capacity for generalization | Nature Methods

Faster. FOSS. FAIR.

#StructuralBiology @strucbio

https://www.nature.com/articles/s41592-024-02272-z

xtaldave, to strucbio
@xtaldave@xtaldave.net avatar

Open letter to Nature editors complaining about the lack of code availability for AF3 (Publishing code is normally a prerequisite for publishing in Nature)

(Yes, I am fully aware of the irony of using a Google form to do this - not my idea, just sharing.)

@strucbio

https://docs.google.com/forms/d/e/1FAIpQLSf6ioZPbxiDZy5h4qxo-bHa0XOTOxEYHObht0SX8EgwfPHY_g/viewform

xtaldave, to Eurovision
@xtaldave@xtaldave.net avatar

Gotta flog that merch .

xtaldave, to Georgia
@xtaldave@xtaldave.net avatar

She's singing about the sun and fire whilst a geomagnetic storm hits? Coincidence?

xtaldave, to Eurovision
@xtaldave@xtaldave.net avatar
xtaldave, to Eurovision
@xtaldave@xtaldave.net avatar

The EBU is currently in a crisis meeting, according to information on SVT.

https://www.svt.se/kultur/senaste-nytt-om-eurovision-song-contest-2024

xtaldave, to random
@xtaldave@xtaldave.net avatar

BBC News: Sunak says it'll take time for people to feel better - BBC News

Yup. After the election when your fucking arse has been handed to you, and you've fucked off to silicon valley you rat-faced cunt.
https://www.bbc.co.uk/news/articles/cmm3gzz1dj3o

xtaldave, to science
@xtaldave@xtaldave.net avatar

They reconstructed 1 cubic millimetre of human brain. It contains 1.4 petabytes of electron microscopy data, 150,000,000 synapses. 57,000 neurons.

Huge amount of work. For 1 cubic mm. The Brain is hardcore.

A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution | Science https://www.science.org/doi/10.1126/science.adk4858

xtaldave, to science
@xtaldave@xtaldave.net avatar

Alphafold 3 server has dropped, kids. https://golgi.sandbox.google.com/about

Can do select small mols, PTMs, Nucleic acids and ions.

#StructuralBiology @strucbio #Science #Research #Crystallography #CryoEM #NMR

xtaldave, to environment
@xtaldave@xtaldave.net avatar

Well, shit.

BBC News - Climate change: World's oceans suffer from record-breaking year of heat
https://www.bbc.co.uk/news/science-environment-68921215

xtaldave, to hamburg
@xtaldave@xtaldave.net avatar

People of Hamburg!
I shall be visiting Hamburg this weekend.
Ostensibly, this is for work (Friday) but I may have accidentally tacked on a couple of days extra to explore the city.

I now realise this is the weekend of the Harbour festival, so this is either a very good or a very bad weekend to visit (ymmv).

Suggestions for eateries (plant based) and other fun things to do gratefully accepted.

.

xtaldave, to random
@xtaldave@xtaldave.net avatar

Jesus, the fucking wheels are falling off now?

BBC News - Have the wheels come off for Tesla?
https://www.bbc.co.uk/news/business-68947020

xtaldave, to random
@xtaldave@xtaldave.net avatar

Happy Star Wars day to those who celebrate.

xtaldave, to random
@xtaldave@xtaldave.net avatar

Excellent work everyone

xtaldave, to random
@xtaldave@xtaldave.net avatar

Anger as homophobic piece of shit George Galloway says gay relationships aren't 'normal'

“Three of my children go to a Catholic school in Scotland, so they have some protections for the moment,” -- ah yes, the catholic church, world renowned for absolutely 100% not abusing kids.

https://www.thepinknews.com/2024/05/02/george-galloway/

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