CastlTrAstonDrs,
@CastlTrAstonDrs@med-mastodon.com avatar
CastlTrAstonDrs,
@CastlTrAstonDrs@med-mastodon.com avatar

Low levels might explain some symptoms, study proposes. Viral infection appears to influence blood concentrations of the chemical messenger—but the connection to cognitive impairment remains murky @ScienceMagazine.
https://www.science.org/content/article/low-serotonin-levels-might-explain-some-long-covid-symptoms-study-proposes

CastlTrAstonDrs,
@CastlTrAstonDrs@med-mastodon.com avatar

@NatGeo What causes / ? The answer might be from the gut . Study shows that remnants of the virus in the gut cause chronic inflammation which may disrupt communication with https://www.cell.com/action/showPdf?pii=S0092-8674%2823%2901034-6.

image/png

CastlTrAstonDrs,
@CastlTrAstonDrs@med-mastodon.com avatar

Nearly 1 in 5 people who have had in 🇺🇸 https://www.cdc.gov/nchs/pressroom/nchs_press_releases/2022/20220622.htm
Depletion of serotonin disrupts gut-to-brain communication, which can cause Neurological sx “brain fog” & impaired memory. As resulting in LC through a pathway that originates in the gut & leads to reduction. connects with gut & uses the neurotransmitter serotonin to communicate and regulate many biological & neurological functions

image/png

CastlTrAstonDrs,
@CastlTrAstonDrs@med-mastodon.com avatar

such as mood, digestion, appetite, learning and memory, immune response, heart rate, among others https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859128/ Previous studies had shown that fragments of 🦠 that linger() in patients after the initial infection heals .These ‘tails’ of postacute infection syndromes (PAISs) can cause chronic inflammation development https://www.nature.com/articles/s41591-022-01810-6

CastlTrAstonDrs,
@CastlTrAstonDrs@med-mastodon.com avatar

tissue damage, in some cases disrupt communication in the nervous system. https://www.science.org/doi/10.1126/science.abm8108 also interferes with the levels of several metabolites during the initial infection. Patients not only have lower levels of https://www.rcpjournals.org/content/clinmedicine/21/1/e63
but these imbalances can persist in those with
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9111264/

image/png

CastlTrAstonDrs,
@CastlTrAstonDrs@med-mastodon.com avatar

These remnants of 🦠(a ) trigger the immune system to release virus fighting proteins ( ). The extended release of interferons caused chronic inflammation in lab mice & in LC patients https://www.nature.com/articles/s41590-021-01113-x Reduced levels due to in 🐁 disrupted their signaling & 🐁failed to distinguish new objects from familiar ones in tests.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332351/

CastlTrAstonDrs,
@CastlTrAstonDrs@med-mastodon.com avatar

This failure mimics neurological symptoms, such as brain fog, generally associated with in humans.
🧪Can help?
Some common antidepressant drugs, called selective serotonin reuptake inhibitors (SSRIs),such as Prozac & Sarafem boost mood by increasing serotonin in the brain. When scientists gave Prozac to sick mice, it improved their performance in recognition tests. Supplementing the 🐁 food with , which improved levels of serotonin, also helped.

CastlTrAstonDrs,
@CastlTrAstonDrs@med-mastodon.com avatar

🧪Can boosting levels treat ?
's might be useful in treating, or even preventing LC. When scientists gave Prozac to the lab 🐁 whose neurological symptoms mimicked LC because of viral infection—it restored their memory loss.
https://www.medrxiv.org/content/10.1101/2022.11.09.22282142v3

CastlTrAstonDrs,
@CastlTrAstonDrs@med-mastodon.com avatar

SSRI known under the brand names Luvox and Faverin, which is prescribed to treat major depressive disorder, obsessive–compulsive disorder, & post-traumatic stress disorder did not prevent https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00299-2/fulltext And fluvoxamine at a dose of 50 milligrams twice a day during acute infection also did not prevent the development of LC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9945922/

CastlTrAstonDrs,
@CastlTrAstonDrs@med-mastodon.com avatar

scientists warn patients against self-medicating with antidepressants to treat LC. If the levels of serotonin in 🧠 become too high, it can cause serotonin syndrome—a rare but serious condition with symptoms such as seizures, irregular heartbeat & unconsciousness.
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00299-2/fulltext

CastlTrAstonDrs,
@CastlTrAstonDrs@med-mastodon.com avatar

New research shows that remnants of the virus in the gut cause chronic inflammation—which may disrupt communication with the brain. Can antidepressants help?
https://www.nationalgeographic.com/premium/article/long-covid-serotonin-antidepressant-ssri

CastlTrAstonDrs,
@CastlTrAstonDrs@med-mastodon.com avatar

Treatments
Efficacy & safety of in patients with
https://www.sciencedirect.com/science/article/pii/S2405844023073619
Oral azvudine for mild-to-moderate in high risk, nonhospitalized adults
https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.28947
Oral Azvudine for hospitaliseds patient & pre-existing conditions.
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00158-X/fulltext

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