@Holberg I'm shorter on patience now, which I regret, but... gestures at everything... so I'm quicker to unfollow than I used to be. (To be fair. there are also more drains on my mental health so I can't afford those that are easy to avoid.)
Beyond the obvious criteria (bigotry, etc.), I now unfollow for topics that make me sad or exhausted: pandemic naivete, tech gullibility, amplifying propaganda, steady bleakness beyond my filtering capacity. It's not personal, it's survival.