Strange there’s no mention of crohns or colitis in this article. Both are monitored through calprotectin and you would expect a strong correlation between IBD and Alzheimer’s in this case
My immediate thought. People with those conditions literally spend their entire lives, or most of it, with their guts inflamed. It’s only recently that they’ve come up with the biological medicines that can truly suppress it effectively for long periods of time.
You’d think they’d have spotted a noticable correlation by now if there was one.
I have crohns and it resulted in the loss of my entire colon. Every time someone talks to me about the disease, they have no respect for it because they don’t know what it is.
I was saved by modern medicine and am currently saved by it. And the advances that saved me are many. Those drugs you mentioned, surgical advances, dieting, all of it. If it weren’t for those, I would have died of organ failure my sophomore year of college.
So to your point, why would they not have spotted it or noticed? Well, I think that severe cases of crohns and UC used to just kill you. But nowadays the diseases are mostly studied under the same umbrella. Crohns and UC present different, but any inflammatory autoimmune disease is similar and could have similar causes. There’s also more info that we’re getting about the brain and gut relationship. So if I had to guess based on current info I’ve found on the diseases, it’s a diet problem.
I expect huge leaps to be made on autoimmune stuff, it could even be solvable through CRISPR.
Bendlin urged caution in interpreting the relationship between inflammation and Alzheimer’s, as additional research is needed to understand whether there is a cause-and-effect link.
“We can’t infer causality from this study; for that, we need to do animal studies,” she said.
Inflammation inflammation inflammation everything is inflammation let’s just put all our research towards inflammation since it seems to be the root cause of everything
We already kind of know how it works! The Alzheimer’s plaques are a malformed version of a brain protecting protein. It’s production can be triggered by inflammation. The protein is supposed to help you in case of emergency, but if you have Alzheimer’s, it forms into plaques and makes your neurons die.
Perhaps. Causality has yet to be determined in that case, it seems.
But anyway, I swear I have seen several articles about studies in the last few years that indicate inflammatory responses can cause other problems. (No just covid).
Something is causing the inflammation, then the inflammation causes something else. In that case you wouldn’t treat the inflammation, you would treat the cause of the inflammation.
I’m getting the vibe that all of the “we can’t explain this” psychiatric disorders are autoimmune diseases. And famously the gut and immune system are very tightly connected. So this makes sense to me.
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