Possibly, now that we have much tighter integration between different chips using die-to-die interconnects like Apple's "UltraFusion" and AMD's "Infinity Fabric" to avoid the latency and microstutter issues that came with old-fashioned multi-GPU cards like the GTX 690 and Radeon HD 7990 XT.
As long as software can make proper use of the multiple processing units, I think multi-GPU cards have a chance to make a comeback... at least if anyone can actually afford the bloody things. Frankly, GPU pricing is a bit fucked at the moment even before we consider the idea of cards with multiple dies.