I don't have experience but have heard from many that it is easy to over inflate with cartridges. The convenience does not outweigh the danger of not having a cartridge when you need one. A mini pump won't do that. Have you considered solid, flat free tires? A little extra weight and expense but an option.
@stfn lezyne has a tiny bike pump that you can also use with cartridges. I have the one and after paying for a few cartridges I decided I couldn’t justify buying more.
@stfn Don't not bring your minipump if you're going on a long trip. You don't want to end up popping a tube and then being stuck without enough air to finish your trip. Yes you can bring multiple cartridges, but CO2 can pass through the valve a lot easier compared to regular air so you'll end up with a flat in the morning anyway
@robryk@stfn I can't remember all the science but something about the differences in permeability and size of the molecule, as well as the thermal properties between the two
A set of random people on the internet (after excluding ones that say things that can't be real) is reasonably unanimous in claiming that it's because co2 is in some way "soluble" in solid rubber. See e.g. https://www.madsci.org/posts/archives/may98/895552329.Ch.r.html
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