And if Meta tries to pull some sort of destructive shenanigans, sure, then defederate from them. Not because they're Meta, but because they're pulling destructive shenanigans. There's already plenty of instances that get defederated for that sort of thing.
That's not what I'm annoyed about here, though. I'm annoyed by all the people who have come to the Fediverse claiming that it's because it's open and free and all that, and then when some company that they have a particular personal dislike for comes along and wants to participate in the protocol exactly as intended they go "but not like that!"
If some random instance like lemmy.ca (name picked randomly) was to find itself in financial difficulty keeping the lights on and was to strike some kind of deal with an advertiser to put banner ads on their site, would there be a similar enormous hue and cry about it? Maybe users on lemmy.ca who have to actually deal with the advertising might raise a ruckus, but over here on kbin.social it wouldn't affect me in the slightest.