Vote for useful things and voting reform at the local level.
Vote for whatever keeps the system itself functioning at the federal level. If one party's leaders are in bed with "presidents for life" or the authoritarian governments that were ratfucked to make them presidents for life, you are going to end up with a president for life.
Important to note: If enough states enact voting reform at the local level, you no longer need a constitutional amendment to have voting reform that influences the federal level. If you are looking for real change, this is where it is. It is slow and unsexy, but don't bitch about your federal vote meaning nothing if you're not doing anything with your local elections.