“tissue samples from 225 patients who had recovered from mild #COVID19 and found that #SARSCoV2 viral RNA was distributed across ten distinct solid tissues, plasma, and blood cells up to 4 months after infection. Importantly, detection of #viralRNA, and higher virus copy numbers, were significantly associated with post-COVID-19 condition (also known as #longCOVID)” https://mastodon.social/@ChristosArgyrop/112320370153243988
“long COVID is associated with persistence of SARS-CoV-2 RNA and proteins in different body tissues and cells. In turn, SARS-CoV-2 persistence might result in long COVID symptoms through direct host-cell changes, immune activation, latent virus reactivation, or combinations of the three.”
“From an immune activation perspective, recent studies have found that patients with long COVID have complement dysregulation with signs of thromboinflammation, higher concentrations of circulating non-conventional monocytes associated with various chronic inflammatory conditions, and a T-cell phenotype consistent with T-helper-2-cell-skewed CD4+ T-cell activation.”
“concentrations of IgG against SARS-CoV-2 spike and S1 in participants with long COVID were higher compared with vaccination-matched controls, suggesting persistent viral antigens. Even more strikingly, Peluso and colleagues observed T-cell activation up to 2·5 years after SARS-CoV-2 infection, especially in areas of the body such as the gut where SARS-CoV-2 RNA was identified, suggesting that tissue viral persistence could be associated with long-term immunological perturbations”
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