Changing to 48V allows you to use thinner wires and smaller connectors but it comes at several costs:
Most low-resistance (RDson) mosfets used in buck converters are only rated to 20V or so. The higher voltage rated ones tend to have higher resistance which would cause more heat losses in your buck converter. At a few hundred watts output even a few % loss in efficiency is a lot of power, so you will either need to pay more money in cooling+heatsinking of the converter or more on fancier fets.
A faulty connector will arc a lot more badly with 48V than 12V. The arc will strike more easily, sustain more easily and dump much more heat (vaguely 16x as much if you use an equivalent-ohmic estimate, but I suspect plasma physics doesn’t work that way).
Fuses for 48V are more expensive than 12V. Arcs/plasma inside fuses is harder to quench with higher voltages (because of the higher potential transient fault current, but also possibly because of different electrochemistry+plasma at the higher voltages?).
Bucking 48V to the 1.1V or so that GPU’s and CPU’s use is a ratio of almost 50:1. That means the buck converters need to use a very low duty cycle (which causes some technical problems with mosfet driving & controller choice) or you need to move to using a transformer instead of an inductor. That’s all doable and kind of cool, but might (?) have extra costs involved.
If we ignore the industry transition costs then things might still end up more expensive at the end of it. Not sure, I work mostly at lower voltages to avoid these problems.
The future lies with 3-phase-480VAC-directly-into-card via the PCIE slots >:)