You can do that, Brave even prevents uBlock Origin from beeing fingerprinted. uBlock Orgin has some additional features which Brave Shield’s hasn’t, but they are only useful if u use them, so you don’t necessary need uBlock Origin on top. Just if you want some of it’s features which Brave has not, like Medium and Hard Mode.
Depends on what block lists you use and how aggressive you want the filtering to be. I've been using Brave for a while and tested it with and without uBO. With Brave Shield set to aggressive blocking (what I higly recommend) it blocked about 99,5 of all the stuff uBO would block.
By default, Brave has the strongest privacy protections of any popular browser. And Shields are a core part of that protection. Here’s a long list of what they can do: Block third-party ads & trackers
Third-party ad & tracker blocking, on every page you visit. Available in Standard and Aggressive mode.
Resource replacement: Brave will block-and-replace problematic resource scripts with a stripped-down, more private version that still allows the page to function. Learn more about Brave’s “SugarCoat” work with UC San Diego.
CNAME uncloaking: Some third-party trackers use cloaking tactics to hide where code really comes from, and circumvent ad blockers. Brave can see through this evasion, and stop it from happening.
Anyway, the best browser for privacy is always Firefox, you need to customize the settings and add add-ons for this purpose, then it’s even more powerful than Brave.
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