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I'm copying a public post below from an interesting Assistant Professor of Philosophy and Data Science at UNCC (not a medical doctor or psychologist).
Everything he is discussing is TENTATIVE but very interesting. I'm sending this out now because there is so little in the popular press about what can actually be done to help people with brain fog and other Long COVID symptoms. The research is still very early, and of course medical professionals should be consulted.
The article link from Nature Magazine describes brain damage caused by SARS-CoV-2 related to cell death and especially to synapse loss, leading to cognitive impairment.
The study in Bioelectric Medicine is extremely small, yet shows the potential of nicotine patches in the treatment of Long COVID symptoms including brain fog. (Another paper from the same publication also goes into why nicotine might help with Long COVID: https://bioelecmed.biomedcentral.com/articles/10.1186/s42234-023-00104-7 )
He then points to a study on the NIH PubMed site reporting the encouragement of synapse growth from psilocybin.
A comment in the discussion thread also links to a British Medical Journal article on Metformin improving Long COVID symptoms ( https://www.bmj.com/content/381/bmj.p1306 )
There's further speculation in the discussion thread that other psychoactive substances might be helpful. There are perhaps AI bots in the discussion thread discussing psilocybin microdosing, so be aware of that and maybe not get excited that so many "people" are discussing it.
From: <https://ourislandgeorgia.net/@Wolven/111412769611401616>
Dr. Damien P. Williams
@Wolven
…HUH. Long-COVID destroys synapses, and is a major contributor to the brainfog. <https://www.nature.com/articles/s41380-022-01786-2>
This goes some way to shining a light on the promising results they've been seeing in testing nicotine patches as treatment for long covid: nicotine effects synapse formation and receptivity (tests using patches because they don't habit-form and aren't, y'know, SMOKE [<https://bioelecmed.biomedcentral.com/articles/10.1186/s42234-023-00104-7>]).
But what's super interesting to me is that another thing that's also been shown to encourage synapse growth? Is psilocybin.
<https://pubmed.ncbi.nlm.nih.gov/34228959/>
From: <https://ourislandgeorgia.net/@Wolven/111412769611401616>
~~~
#psychology #counseling #socialwork #psychotherapy #research @psychotherapist@a.gup.pe @psychology@a.gup.pe @socialpsych@a.gup.pe @socialwork@a.gup.pe #Vaccines #COVID #longcovid #science #medicine #hospital #brainfog #sarscov2 #metformin #nicotine #nicotinepatch #psilocybin
In case anyone else is confused, (I was), the two papers on Metformin I posted are in fact the same clinical trial paper.
medRxiv preprint was posted June 7, Lancet version was posted June 8. This is unusal to see preprints & journal version back to back like this. There were alot of changes between the two (which is typical).
I hate that it takes so much time to prove when something isn't "all in our heads".
"Was anyone else seeing what I was seeing? The researchers had not only shown that Long Covid might be preventable simply by taking a low-cost drug. They’d provided the best objective scientific proof that Long Covid measurably exists that I’d ever seen, or have seen since."
So much for thru-hiking the #AppalachianTrail this year. I've been on a downward spiral since leaving my job in September 2022. I was professionally burnt out. I didn't want to keep building #backend#dotnet APIs. I also read through the latest #IPCC reports, which paint a bleak picture of our collective future. In short, I was miserable.
I quit my meds cold turkey -- #Lexapro and #Metformin -- and started downsizing my life. I got a job as an #Amazon warehouse worker, but left after a few weeks as the holidays ramped up while the pay stayed the same. #DoorDash became my only source of income.
I also threw myself into political activism, working with the #PartyForSocialismAndLiberation to fight off an Austin Energy rate hike that punished the poor with big rate hikes while giving cuts to the wealthy. We won a few minor concessions, but the disparities were still there.
Afterwards, I sold or donated most of my possessions to try to pay my bills. I even sold my car eventually once DoorDash stopped paying well. I took the remaining cash and geared myself for a thru-hike of the AT, convinced that I could walk myself to a better place physically and mentally.
Physically, by mid April of 2023, I certainly felt ready. I was doing 15-mile days in #atx#austin. But mentally, I was still struggling with suicidal ideation every few days. My mom had booked flights and a hotel to see me off at #AmicalolaFalls, and the week before, she picked me up and brought me to her place.
It took all of 48 hours for her to chip away what little facade of confidence I had left. I broke down crying, saying I was at least passively suicidal, had crazy #anxiety and #depression, my blood sugar was all kinds of fucked up on account of not taking my #diabetes meds, and, above all, I was not (mentally, at least) ready to spend months in the mountains, alone.
So now I'm here, in Benbrook TX, back on meds, back at home (again (at 33)), going to #therapy, going bankrupt, and trying to figure out how to survive in #LateStageCapitalism and not end it all.
At this point I'm out of the nosedive at least. But I've got a bunch of climbing to do in the meantime.
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