In addition to what we’ve shown in our preprint, we now also show that optogenetic silencing of the dorsal hippocampus-accumbens pathway leads to reduced appetitive licking near the reward zone. Plus, a lot more analysis and statistics in the supplement!
This was a massive team effort with huge help from my supervisor
Stefan Remy, my fantastic colleague @petra_moce, and feedback and encouragement from many friends and colleagues (esp. PakanLab@mastodon.world) that have helped carry this through a pandemic, paternity leave, and a lab move.
How the brain spoils your appetite: A research team around Rüdiger Klein found the brain circuit that suppresses appetite when feeling nauseous. Special nerve cells are activated during nausea and elicit appetite-inhibiting signals which prevent eating.
#IDMastodon#neurocovid#publichealth Acute #COVID19 cases indicates a concerning association with cognitive deficits in the general population, regardless of #COVID clinical course and severity or with no association with any blood inflammatory marker. A recent study suggests that even in mild cases ,#SARSCoV2 infection promote systemic endothelial dysfunction, impair the homeostatic mechanism of neurovascular coupling and promote white matter damage.
#neurocovid cognitive dysfunction has been described in 43% of patients and associated with younger age . Findings indicate a potential ongoing injury affecting #neurons & #astrocytes following #SARSCoV2 negativization,still evident 10 mths after negativization.This phenomenon appears to be more pronounced in individuals experiencing cognitive impairment 1 wk post infection.
Aging is associated with changes in #neurons thought to drive motor, sensory, and cognitive impairments. Using a Drosophila model of #aging, @Natsansor &co report that deterioration of the microtubule cytoskeleton is an important driver of neuronal aging.
#Schwann cells are known to act as an insulating layer around nerve fibers. They protect and provide nutrients to #neurons. Yet a study by the labs of @GaryRLewin1 and James Poulet has shown that specific types of Schwann cells are also actively involved in detecting pain and touch.
First authors: Julia Ojeda Alonso, Laura Calvo Enrique, Ricardo Paricio-Montesinos.
The paper was published in “Nature Communications”.
✅A method for predicting mega-floods 🌊
✅An unknown earthworm 🪱
✅A protein that protects our #genes 🧬
✅The impact of urban #green spaces on our #health 🌳
✅A chip for cultivating #microbes and #neurons 🦠
✅A programme to facilitate breast surgery 🔢
✅Endangered Old World fruit #bats 🦇
[...]
Researchers from university labs in the U.K. are developing models of brain cell interactions using a company's synthetic human cells derived from stem cells.
Antibody/Gene Therapy Biotech Gains $138 Million in Early Funds
A developer of synthetic antibodies for neurodegenerative disorders delivered like gene therapies is raising €129 million ($US 138 million) in its first venture funding round.
I thought I would share my portrait of neurologist Santiago Ramón y Cajal (1852 - 1934) for #VirtualArtOfNeuro. It shows him as a young man in front of Purkinje and granule cells from a pigeon, based on one of his own drawings. 🧵1/2
"A team of New York University neuroscientists has now identified a class of neurons -- what it calls "prediction-error neurons" -- that are not responsive to sounds in general, but only respond when sounds violate expectations, thereby sending a message that a mistake has been made.
"Brains are remarkable at detecting what's happening in the world, but they are even better at telling you whether what happened was expected or not," explains David Schneider, an assistant professor in NYU's Center for #NeuralScience and the senior author of the study, which appears in JNeurosci. "We found that there are specific #neurons in the brain that don't tell you what happened, but instead tell you what went wrong." https://www.sciencedaily.com/releases/2023/10/231006104510.htm