Clever neuronal activity labelling strategy: Engineered Ca2+ sensor biotinylates nearby proteins. Those proteins can then be stained - works for single vesicles, organelles, dendritic compartments, all the way to neuronal engrams. Both in culture and in vivo!
Here's one of the few more modern articles I found about this Arc gene and how brains work. "Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405677/
The Neuroscience department at SISSA is hiring! We are looking for candidates for multiple assistant professor (tenure track) openings across a broad spectrum of topics in neuroscience (molecular, cellular, circuit, systems, cognitive and computational). SISSA is an international school in Trieste, Italy, promoting basic and applied research in Neuroscience, Mathematics and Physics and dedicated to the training of PhD students.
@Centurion480@JonChevreau Okay cool etc. but is there a study showing the benefits of long workdays in a chair followed by evenings watching TV in a recliner while consuming 2-4 martinis? Because honestly I'm more exhausted after those than I am after exercise, so it must be as healthy as exercise, right?
@msbellows@JonChevreau We're bipedal tetrapods optimized for constant movement and running away from lions in the Serengeti of Africa. So, I'm sorry, but I don't think there are studies supporting your proposition.
What can we learn about our senses from people who were born without them?
We think of perception as a passive, mechanical process, as if our eyes are cameras and our ears microphones. But as neurobiologist Susan R. Barry argues, perception is a deeply personal act. Our environments, our relationships, and our actions shape and reshape our senses throughout our lives.
What we think about and focus on, impacts on us emotionally and physically, so a choice to be appreciative - even despite tough times - elevates your immune system as well as your attitude.
This trains your brain and body to be in an increasingly positive state.
Tethered flies learn to turn either to the left or to the right to avoid a punishing heat beam.
Using CRISPR/Cas9 to knock-out the gene "atypical protein kinase C" or aPKC, graduate student Andreas Ehweiner found out that aPKC was necessary in cells that also express the gene FoxP:
Analyzing expression patterns, collaborator Carsten Duch discovered that motorneurons that innervate direct muscles controlling turning direction express both aPKC and FoxP. To do this he had to dissect the tiny mscules that attach to the wing hinge on an already tiny fruit fly! Using confocal microscopy, he identified the motor neuron terminals on the muscles which show labels reporting expression of both genes: