@axoaxonic@synapse.cafe
@axoaxonic@synapse.cafe avatar

axoaxonic

@axoaxonic@synapse.cafe

Studying mathematical/theoretical/computational neuroscience & data science in dᶻidᶻəlal̓ič (Seattle) -- more interested in studying nervous systems through abstraction than studying neurons to improve artificial systems

⚧ ND (ASD/mTBIs/cPTSD/ET/probably more letters) ⬛

Long time musician, now slowly inching my way thru academia as first in my close family to do so. Grew up unschooled, which gave me a heavy autodidactism habit

CW: Posts about disease, links to research involving animals

This profile is from a federated server and may be incomplete. Browse more on the original instance.

axoaxonic, to random
@axoaxonic@synapse.cafe avatar

Sometimes following the standard practice makes things not work as well. Like, it'd be so much easier for me to read math equations if the variables were named first, instead of writing out this huge equation then saying "where B denotes the constant parameter ... " after. Why are most equations written like this?

whitequark, to random
@whitequark@mastodon.social avatar

does anyone know a technological solution to "hands are too shakey for SMD soldering"? I am thinking of some sort of device you can place your hand on that dampens the tremors
(please RT, would really love for my gf to be able to solder fine pitch SMD stuff)

axoaxonic,
@axoaxonic@synapse.cafe avatar

@whitequark I pretty much gave up on learning electronics hardware because of fine motor disability, but I did try asking about this in an embedded engineering discord server and they suggested: getting someone else to do the soldering for you, using PCB vices and taping things down, and using a PNP machine. I found this list of "OpenPNP" projects https://openpnp.org/hardware/ that might be a little cheaper.

The gundam model hand stablizer seems really helpful but it might be more for lower frequency hand & arm oscillations, i wonder how much it'd help higher frequency finger osc

axoaxonic, to random
@axoaxonic@synapse.cafe avatar

"Comparing Dendritic Trees with Actual Trees"
R. Farhoodi, P. Wilkes, A.N. Natarajan, S. Ing-Esteves, J.L. Lefebvre, M. Disney, K. Kording, 2023
https://arxiv.org/pdf/2307.01499.pdf

axoaxonic,
@axoaxonic@synapse.cafe avatar

Glad they actually did this. I always look up at trees and think of how they compare to dendrites, how they both share branching patterns defined by environment and available resources, shortest-path active diffusion with self avoidance. Enjoying this in-depth modeling based analysis

jonny, to random
@jonny@neuromatch.social avatar

one thing I would like the neuroscientists to answer for is why in the hell dreams are so vivid when you have been smoking weed for a few nights in a row and then stop. I am just having my world rocked by dreams rn

axoaxonic,
@axoaxonic@synapse.cafe avatar

@jonny I have to find the ref for this because I was trying to figure this out a few years ago. It definitely changes the way the BLA talks to the hippocampus, changing the theta rhythms. It generally affects short term memory, and all dreams after waking are memories of dreams.

More speculatively, PGO waves https://en.wikipedia.org/wiki/PGO_waves & https://www.frontiersin.org/articles/10.3389/fnhum.2017.00089/full happen during REM sleep and may play a role in dreaming. PGO waves might originate in the parabrachial area of the pons which surrounds the bridge between the cerebellum and the pons, the superior cerebellar peduncle https://doi.org/10.1023/A:1026398402985
The molecular layer of the cerebellum has a "particularly high densitity" of endocannabinoid receptors (Ito, 2012), so there's a possibility that adding an agonist could effect dreams through altering PGO waves, but I don't think the relationship between cerebellar endocannabinoid receptors and PGO waves has been looked at, if there is one at all

elduvelle, to ArtificialIntelligence
@elduvelle@neuromatch.social avatar

What’s the best equivalent to an “old-school” Thinkpad laptop, these days? I had a X200s and really liked its keyboard and durability… and yes the red trackpoint too!
(Please don’t say the new Thinkpads… their keyboard is meh)

axoaxonic,
@axoaxonic@synapse.cafe avatar

@elduvelle How close to new ThinkPad can you get by just upgrading the hardware of an old ThinkPad?

axoaxonic, to Neuroscience
@axoaxonic@synapse.cafe avatar

is an extremely complex umbrella of many subspecialties. If you work in neuro, how did you choose which specific area[s] to focus on?

One thing that holds me back often is that I have an impairment in decision making. Inspiration from and communication with others about their processes helps

axoaxonic,
@axoaxonic@synapse.cafe avatar

@elduvelle When I found out about place and grid cells I watched multiple lectures and read papers by Ila Fiete and the Mosers, read about how the p6m symmetry group can tile the Euclidean plane, wrote notes about how the brain might use that plus symmetry breaking to represent movement and invariants in the environment, etc. I always spend hours and hours on anything I find interesting, but I've found so many different specific things to do that with. I can't get hooked on just one like that, there is no hierarchical categorical structure to my interests and everything seems super important and worthy to be hooked on.

After collecting thousands of papers and books, reading hundreds of them, taking hundreds of pages of notes, there's still not "favorite." There's only stuff I keep coming back to over the years, which kind of narrows it down, but is still a big list. It's nice to have affirmation from your reply and others that everyone does wear many hats. Maybe I can find a program or lab that supports such hat stacking.

axoaxonic, to random
@axoaxonic@synapse.cafe avatar

Daniel Bennequin, "Geometrical invariance in movement generation"
https://www.youtube.com/watch?v=0afatBG4ogE

and a related book, "The Brain’s Sense of Movement" by Alain Berthoz
https://www.hup.harvard.edu/catalog.php?isbn=9780674009806

I'm curious how this type of work can also be applied to movement differences away from the norm, like disorders and pathologies

aledaus, to random

Cerebellum + Basal Ganglia

In my opinion, one of most fascinating system
area...

A 2018 "primer" here:
https://pubmed.ncbi.nlm.nih.gov/29643480/

And a recent PNAS paper -->
@PNASNews

https://www.pnas.org/doi/10.1073/pnas.2221641120?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Here is an extract from their abstract:

"Even in the absence of movement, the cerebellum and basal ganglia are known to be activated during rhythm perception. To understand their roles, we examined neuronal activity in monkeys performing behavioral tasks in which sensory and motor processing of rhythm were spatially separated. We found that neuronal activity in the cerebellum varied with the location of periodic visual stimuli and that in the striatum varied with the direction of prepared movement. These results suggest that the flow of information from sensory prediction to motor preparation during rhythm processing is upstream in the cerebellum and downstream in the basal ganglia, although there is considerable overlap."

axoaxonic,
@axoaxonic@synapse.cafe avatar

@aledaus I have a bad habit of replying to threads with reading recommendations, but here's this too:

https://link.springer.com/book/10.1007/978-0-387-84868-6

The authors go into detail about these connections and relate their roles in motion planning and execution to cognition

ttpphd, to tech
@ttpphd@mastodon.social avatar

Interesting way to create a transducer for a speaker. First create a diaphragm with a rubber membrane (an electric insulator), covering the rubber membrane in conductive grease to make an electrode. Then you can deform the membrane using an electric signal. The article has a nice diagram and explanation.

https://www.polytechnique-insights.com/en/columns/science/loudspeakers-new-materials-in-acoustics/

axoaxonic,
@axoaxonic@synapse.cafe avatar

@ttpphd This is really cool, I have to send it to my friend who makes amps

deilann, (edited ) to random

When you see someone using one of those "technically correct" Latinate or Greek plurals where the English standard variation is now typically considered accessible and is quite common, does it impact how you view the writer or writing? (Impact here can be positive or negative, whic is partially why I request more details!)

Examples:

  • formulae vs formulas
  • fora vs forums

I'm not asking in situations where someone is being corrected, simply when you see the traditional plural being used.

Please comment with details if you so choose! I'm really curious. I'll be commenting with my own (and my answer would be yes).

Boosts welcome.

axoaxonic,
@axoaxonic@synapse.cafe avatar

@deilann It increases the distance between the language of what I'm reading and how a lot of the people I've been around my whole life actually talk, and that can feel alienating. But that also depends on the other signals coming from the author like references and overall tone. Most of the time I don't think about it though, like "oh this is just how this person writes", and I keep reading for the info

gsuberland, to random
@gsuberland@chaos.social avatar

why is the inanimate carbon rod green

axoaxonic,
@axoaxonic@synapse.cafe avatar

@gsuberland It's actually the inanimate cupric carbonate rod but that was too much to say

axoaxonic, to random
@axoaxonic@synapse.cafe avatar

Does anyone happen to know the phylogenic origins of dorsal root ganglia, or similar structures? Like, are they, or similar structures, present in insect nervous systems?

NicoleCRust, to random
@NicoleCRust@neuromatch.social avatar

Starting a list of all the amazing early career researchers that have made the wise decision to join us on this worthy platform (but might also take an exposure hit for that). Let's all boost and follow!

Let me start with two:

@WorldImagining

@kinleyid

Please add two more (maybe yourself and 1 other?)

axoaxonic,
@axoaxonic@synapse.cafe avatar

@NicoleCRust

! Thanks for the shout-out, and all the great mastodon engagement so far

Em0nM4stodon, (edited ) to linux

Linux Users! What is your favorite distribution? :tux:​✨

axoaxonic,
@axoaxonic@synapse.cafe avatar

@Em0nM4stodon I tried using Arch and I felt like it would be ideal if I was completely obsessed with Linux as my main thing, but I went back to the minimal Debian distribution that I've been using since some hacker friends showed it to me almost 10 years ago, called #!++ https://crunchbangplusplus.org/

axoaxonic, to fediverse
@axoaxonic@synapse.cafe avatar

Is adding a way to save posts as drafts too? I have tabs open with half finished thoughts, I'd rather have them saved somewhere else to come back to

elduvelle, to random
@elduvelle@neuromatch.social avatar

Hippocampal Replay Q&A

What are some things you’ve always wondered about hippocampal ? ⚡​🧠​
They can be simple questions (like: “what’s the longest replay you’ve ever seen?”) or more complex (like: “does replay = thought?”).
Fire away! You might get an answer (not necessarily from me: anyone can answer!)

axoaxonic,
@axoaxonic@synapse.cafe avatar

@elduvelle How do the replay patterns remain stable over time, and what causes them to become unstable? Also, what (at the cellular/pathway level) causes specific activity patterns to reactivate?

axoaxonic,
@axoaxonic@synapse.cafe avatar

@elduvelle
I only have a second but for the first one i meant, how how lossy are the replays. Like, memories may fade or change, recall is often inaccurate or unreliable, so does this reflect in the hippocampal replay?

will add more later ~

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