trendless

Brad, 3 months ago to random

February 22, 2024- “Over the course of chronic infection, SARS-CoV-2 gets exposed to the host’s immune system and other selective pressures that arise from long-term treatment. This can trigger the acquisition of new mutations in the viral genome, leading to the emergence of highly divergent viral variants that can potentially seed new outbreaks in the community. “- https://www.news-medical.net/news/20240222/Persistent-COVID-19-could-drive-virus-evolution-new-study-suggests.aspx

papilio, 3 months ago to novid

hi, I just re-discovered this helpful video about masking. guidance from engineer Aaron Collins.

https://www.youtube.com/watch?v=s3-Hf6wnPds

me, I wear the Aura 9210+
https://www.3m.com/3M/en_US/p/d/v101348002/

@masknerd
@novid

#CovidIsAirborne
#MaskUp

trendless, 3 months ago (edited 3 months ago) to novid

https://www.mdpi.com/2076-2607/12/3/428#

> …the viral load caused by different variants differs only in the first two days after the onset of symptoms, being higher when infections are caused by the delta variant and lower when caused by omicron. Furthermore, the viral load appears to be higher in outpatients compared to hospitalized patients or in cases of death. On the other hand, no differences were found in the viral load produced in vaccinated and unvaccinated patients, nor did it differ between genders.

@novid #CovidIsNotOver

trendless, 3 months ago (edited 3 months ago) to random

https://www.eurekalert.org/news-releases/1034588

> A gut microbial metabolite called 2-methylbutyrylcarnitine (2MBC) plays a role in exacerbating thrombosis -- the formation of blood clots... The results also revealed that 2MBC is accumulated in individuals with COVID-19, potentially explaining why these patients are at increased risk of thrombosis.

🔗 Cell Metabolism, Huang, Li, He, Dai, Huang, and Shi et al.: “Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin a2b1” https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00014-7

trendless, 3 months ago to random

https://www.eurekalert.org/news-releases/1035451

> The researchers studied the sugar coatings on an antibody known as immunoglobulin G (IgG), which is implicated in the immune responses associated with chronic inflammation among participants in two case-control studies. The results of this investigation provide another biomarker for identifying risk of CVD, which could lead to earlier diagnosis of heart disease or stroke. Since CVD worsens with time, early diagnosis is crucial to having a better outcome for the patient. The research team found that the sugar coatings on the IgG were directly related to the risk of a CVD event, most likely through inflammatory effects, and that an IgG glycan score predicted future cardiovascular events independent of other risk factors.

trendless, 3 months ago to random

"it can't possibly cause harm, it's such a small amount! 🤪"

https://phys.org/news/2024-02-pesticide-exposure-affect-fish-generations.html

> Fish exposed to some pesticides at extremely low concentrations for a brief period of time can demonstrate lasting behavioral changes, with the impact extending to offspring that were never exposed firsthand, a recent study found.

trendless, 3 months ago to WFH

https://arstechnica.com/science/2024/02/rto-doesnt-improve-company-value-but-does-make-employees-miserable-study/

> Data is consistent with bosses using RTO to reassert control and scapegoat workers.

#RTO #WFH

trendless, 3 months ago (edited 3 months ago) to mecfs

#LongCovid #MECFS questions:

In the quest to help a family member understand their fatigue...

a) What measurements/metrics can be useful to self-track/identify what's causing fatigue? (E.g., O2sat, BP, HR, EKG, BG)

b) What can MDs look for beyond standard 'surface-y' tests that may get at the root cause?

:boostRequest: :comments:

trendless, 3 months ago (edited 3 months ago) to random

Wanna save healthcare? Start wearing a mask and ask that your providers do, too.

Simple as.

trendless, 3 months ago to random

Tell me again how it's iNfLaTiOn?

> Loblaw Companies Ltd. set an all-time high for the second time this week as Canada’s biggest grocer rallied on a fourth-quarter earnings beat and expansion plans.

🔗 Canada's biggest grocer hits all-time high twice in one week https://www.bnnbloomberg.ca/canada-s-biggest-grocer-hits-all-time-high-twice-in-one-week-1.2038195

trendless, 3 months ago to random

• In 2018, Boom et al. stated that ethylmercury does not cross the blood-brain barrier.

• Ethyl- and methylmercury cross the blood-brain barrier using the same LAT system.

• To date, 22 studies show that ethylmercury exposure results in mercury in the brain.

🔗 Examining the evidence that ethylmercury crosses the blood-brain barrier; Janet K. Kern a b c, David A. Geier a b, Kristin G. Homme d, Mark R. Geier; Environmental Toxicology and Pharmacology
Volume 74, February 2020 https://www.sciencedirect.com/science/article/abs/pii/S1382668919301875

trendless, 3 months ago (edited 3 months ago) to random

For anyone who wants to help test, I'd like to trial using Matrix for a voice chat at some point this weekend. If you've got an account on #ZeroesCA, you can get on https://talk.zeroes.ca without much friction. For folks elsewhere, all you need is a Matrix account on a federated server.

#CovidIsNotOver

jeff, 3 months ago to mastodon

So upgrading to the most recent #mastodon version will do absolutely nothing to mitigate the spam waves hitting the instances for the past week.

The reality is the servers causing all of this are the very least likely to actually update their code. Only re

But if you run the actually useful #mastoblock script created by @bacon it can actually do something about it.

https://github.com/grose1/mastoblock

#mastoadmin #fediblock

PacificNic, 3 months ago to random

WTFitis is the secondary pandemic.

Don't worry, though. It oNlY aFfeCtS thE vulNerablE, apparently.

ophiocephalic, 3 months ago to random

"Tyler Perry halts $800m studio expansion after being shocked by AI

US film and TV mogul says he has paused his plans, having seen demonstrations of OpenAI video generator"

…except that, who then will produce the films OpenAI needs to steal and regurgitate for its faked-up demos?

https://www.theguardian.com/technology/2024/feb/23/tyler-perry-halts-800m-studio-expansion-after-being-shocked-by-ai

#cinemastodon

trendless, 3 months ago (edited 3 months ago) to random

#StillCoviding2024

trendless, 3 months ago to random

https://www.nature.com/articles/s41598-024-54613-9

> We enrolled 33 post-COVID patients, all self-reporting cognitive difficulties, and a matched control group (N = 27) for cognitive and psychological assessments. Our findings revealed significant attention deficits in post-COVID patients across both neuropsychological measurements and experimental cognitive tasks, evidencing reduced performance in tasks involving interference resolution and selective and sustained attention. Mild executive function and naming impairments also emerged from the neuropsychological assessment. Notably, 61% of patients reported significant prospective memory failures in daily life, aligning with our recruitment focus. Furthermore, our patient group showed significant alterations in the psycho-affective domain, indicating a complex interplay between cognitive and psychological factors, which could point to a non-cognitive determinant of subjectively experienced cognitive changes following COVID-19.

trendless, 3 months ago to random

Staff say Dell's return to office mandate is a stealth layoff, especially for women

https://www.theregister.com/2024/02/20/dell_rto_mandate/

> Dell's "return to office" mandate has left employees confused about which offices they can use and the future of their jobs – and concerned the initiative is a stealth layoff program that will disproportionately harm women at the IT giant.

trendless, 3 months ago to random

https://medicalxpress.com/news/2024-02-scientists-link-leaky-gut-biological.html

> The Wistar Institute's associate professor Mohamed Abdel-Mohsen, Ph.D., has demonstrated, with his lab and collaborators, a connection between viral damage to the gut and premature biological aging.

> the investigative team analyzed colon, ileum, stool, and blood samples from people living with chronic HIV infection and well-matched controls. Their analysis revealed a significant connection between disrupted gut microbiomes, increased intestinal permeability (leaky gut), and faster biological aging.

> Notably, they observed a connection between accelerated biological aging and the microbiomes of both the colon and ileum, but not the fecal microbiome. This suggests that the location of the microbiome significantly impacts its effects and highlights the importance of sampling intestinal tissues to accurately understand the connection between the microbiome and age.

🔗 Shalini Singh et al, Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging, Microbiome (2024). DOI: 10.1186/s40168-024-01758-4

trendless, 3 months ago to random

Ahh, the heady days of running VMware GSX on an Intel Q6600 :mario_jump:

justyourluck, 3 months ago to random

Just heard an instacart ad.

"This is the longest cold, flu, and allergy season there's ever been!!!!"

OMG Whatever you do DON'T SAY THE WORD "#COVID"!

#StillInAPandemic #CovidIsNotOver #CovidDamagesYourImmuneSystem

#DoYouGetItNow ?

My #MaskUP face will still be here when you start to put the pieces together and have questions. #IWontLaugh because NONE OF THIS IS FUNNY

trendless, 3 months ago to random

https://www.sciencealert.com/a-sprinkle-of-gold-dust-could-help-reverse-symptoms-of-parkinsons-disease

> Scientists are investigating whether an oral drug sprinkled with gold nanoparticles could one day treat neurodegenerative diseases like Parkinson's and multiple sclerosis.

🔗 Evidence of brain target engagement in Parkinson’s disease and multiple sclerosis by the investigational nanomedicine, CNM-Au8, in the REPAIR phase 2 clinical trials https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-023-02236-z

trendless, 3 months ago to novid

https://www.science.org/doi/10.1126/sciadv.adi9379

> Patients with Long Covid symptoms produce an antiviral protein called interferon-γ persistently until their symptoms resolve.

Abstract: after acute infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a proportion of patients experience persistent symptoms beyond 12 weeks, termed Long Covid. Understanding the mechanisms that cause this debilitating disease and identifying biomarkers for diagnostic, therapeutic, and monitoring purposes are urgently required. We detected persistently high levels of interferon-γ (IFN-γ) from peripheral blood mononuclear cells of patients with Long Covid using highly sensitive FluoroSpot assays. This IFN-γ release was seen in the absence of ex vivo peptide stimulation and remains persistently elevated in patients with Long Covid, unlike the resolution seen in patients recovering from acute SARS-CoV-2 infection. The IFN-γ release was CD8+ T cell–mediated and dependent on antigen presentation by CD14+ cells. Longitudinal follow-up of our study cohort showed that symptom improvement and resolution correlated with a decrease in IFN-γ production to baseline levels. Our study highlights a potential mechanism underlying Long Covid, enabling the search for biomarkers and therapeutics in patients with Long Covid.

#LongCovid @novid

RoniP, 3 months ago to random

"Key changes they discovered were differences in the body's ability to generate energy compared to healthy patients. This included lower levels of oxidative phosphorylation—a biochemical process that yields ATP, a molecule that the body uses for energy."

https://www.nationalgeographic.com/premium/article/post-exertional-malaise-me-cfs-exercise-energy?s=09#:~:text=Changes%20to%20the%20body's%20energy%20systems&text=Key%20changes%20they%20discovered%20were,the%20body%20uses%20for%20energy