Does anyone have a very detailed and comprehensive guide on how to scale up a Mastodon server?
I'm pretty noobish to Linux but I can follow guides if they have commands and stuff. Though, the only guides I could find were very light on the commands for certain steps.
My Sidekiq has been getting backed up every now and then with thousands of jobs. Of course they eventually clear out but I'd like to just mitigate it by adding more processes or whatever because I'm not even using 50% of my server resources🤷♂️
Any help would be much appreciated.
PS. My server is currently backed up so if you reply to this, I probably won't see it for a bit.😬
@reinhilde perhaps this might be possible if a service is superfluous/discretionary, but even then... if someone is offering a service to 'the public' for a fee, at what point is excluding a member of the public discrimination?
"Follower counts matter less than view and like counts”.
Discuss!
(Not only the statement itself, but why the head of Threads would say this, at this moment in particular).
@chris sounds like they're only too happy to be the arbiters of who sees what. Users can just rely on them / their algos / their 'wisdom'. Also, if a user's likes aren't high enough, it's because the algos don't think the content is good enough, so rage farm harder, plz.
Would anyone care to recommend a CO2 monitor I can prop up next to my desk to remind me when to ventilate?
Bonus marks if it's both powered and portable, so I can occasionally take it to meetings and opt out when things get too muggy. I don't care about recording numbers over time. UK purchase.
@CStamp I agree it's being misused in myriad ways. Immunity is a very complex subject that public health comms seem never to adequately explain. One of the biggest problems with a coronavirus compared to something like polio or measles is that immunity to disease caused by a coronavirus -- whether induced by vaccine or infection -- wanes orders of magnitude quicker than the latter. Aiming for herd immunity to stop the spread of SARS-CoV-2 was a sham from the very beginning.
@CStamp I agree that entities like the Brownstone Institute and others who were proponents of the Great Barrington Declaration, as well as the politicians and other so-called experts who used them as cover for their eugenicist aims, deliberately misused the concept of herd immunity. However, WHO and CDC also incorrectly posited that herd immunity could be used to defeat SARS-CoV-2. The article I linked in the original post is from years before the current pandemic began and I doubt it's the first piece of literature on the subject as it relates to coronaviruses. The current Let It Rip policies that basically every country has resorted to regardless the leaning of their government are everything that the OG deniers -- those who called both COVID and vaccines a hoax from day one -- could have hoped for, eugenics and all. The only way out -- and imo the only ethical, moral choice -- is to individually and collectively do everything we can to stop those infected with SARS-CoV-2 from being able to transmit it to others, using all the layers in this graphic:
@willaful Aranet is probably the best, Vitalight is probably the cheapest. There are a few others that are decent. Definitely get one with an NDIR sensor.
> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the ongoing global pandemic associated with morbidity and mortality in humans. Although disease severity correlates with immune dysregulation, the cellular mechanisms of inflammation and pathogenesis of COVID-19 remain relatively poorly understood. Here, we used mouse-adapted SARS-CoV-2 strain MA10 to investigate the role of adaptive immune cells in disease. We found that while infected wild-type mice lost ~10% weight by 3 to 4 days postinfection, rag−/− mice lacking B and T lymphocytes did not lose weight. Infected lungs at peak weight loss revealed lower pathology scores, fewer neutrophils, and lower interleukin-6 and tumor necrosis factor–α in rag−/− mice. Mice lacking αβ T cells also had less severe weight loss, but adoptive transfer of T and B cells into rag−/− mice did not significantly change the response. Collectively, these findings suggest that while adaptive immune cells are important for clearing SARS-CoV-2 infection, this comes at the expense of increased inflammation and pathology.
> We investigated the levels of both Spike protein (Spike) and viral RNA circulating in patients hospitalized with acute COVID-19 and in patients with and without PASC. We found that Spike and viral RNA were more likely to be present in patients with PASC. Among these patients, 30% were positive for both Spike and viral RNA; whereas, none of the individuals without PASC were positive for both. The levels of Spike and/or viral RNA in the PASC-positive patients were found to be increased or remained the same as in the acute phase; whereas, in the PASC-negative group, these viral components decreased or were totally absent. Additionally, this is the first report to show that part of the circulating Spike is linked to extracellular vesicles without any presence of viral RNA in these vesicles. In conclusion, our findings suggest that Spike and/or viral RNA fragments persist in the recovered COVID-19 patients with PASC up to 1 year or longer after acute SARS-CoV-2 infection.
"We have a pretty strong inclination to believe the source of circulating spike in plasma of long covid patients may be from the bone marrow megakaryocytes that get infected during acute COVID. If so, constant exposure to spike on surface of circulating plasma EVs can account for persistent immune stimulation, immune exhaustion, and pro-thrombotic events stemming from spike stimulation. Please bear in mind that megakaryocytes from the bone marrow serve as the largest source of circulating plasma EVs (extracellular vesicles). What if these megakaryocytes are the source of spike in long covid?"
> Extracellular vesicles (EVs) are a means of cell-to-cell communication and can facilitate the exchange of a broad array of molecules between adjacent or distant cells. Platelets are anucleate cells derived from megakaryocytes and are primarily known for their role in maintaining hemostasis and vascular integrity. Upon activation by a variety of agonists, platelets readily generate EVs, which were initially identified as procoagulant particles. However, as both platelets and their EVs are abundant in blood, the role of platelet EVs in hemostasis may be redundant. Moreover, findings have challenged the significance of platelet-derived EVs in coagulation. Looking beyond hemostasis, platelet EV cargo is incredibly diverse and can include lipids, proteins, nucleic acids, and organelles involved in numerous other biological processes. Furthermore, while platelets cannot cross tissue barriers, their EVs can enter lymph, bone marrow, and synovial fluid. This allows for the transfer of platelet-derived content to cellular recipients and organs inaccessible to platelets. This review highlights the importance of platelet-derived EVs in physiological and pathological conditions beyond hemostasis.
> More than 90% of total human plasma immunoglobulin G (IgG) is found in a fucosylated form, but specific IgGs with low core fucosylation (afucosylated IgGs) are found in response to infections with enveloped viruses and to alloantigens on blood cells. Afucosylated IgGs mediate immunopathology in severe COVID-19 and dengue fever in humans. In COVID-19, the early formation of non-neutralizing afucosylated IgG against the spike protein predicts and directly mediates disease progression to severe form. IgG lacking core fucosylation causes dramatically increased antibody-dependent cellular toxicity mediated by intense FcγR-mediated stimulation of macrophages, monocytes, natural killer cells, and platelets. The mechanism and the context within which afucosylated IgG formation occurs in response to enveloped virus antigens have remained elusive thus far in COVID-19, dengue fever, and other infections. This study demonstrates that administration of human bone marrow megakaryocytes infected by SARS-CoV-2 into the circulation of K18-hACE2 transgenic mice drives the formation of pathogenic afucosylated anti-spike IgG antibodies, and is sufficient to reproduce severe COVID-19 manifestations of pulmonary vascular thrombosis, acute lung injury, and death in mice.
So…re-watched #VforVendetta (2005) after almost 20 yrs & let's just say the Wachowski sisters-McTeigue adaptation of a Thatcher-era comic, swims in a sick miasma of #DejaVu, bolding how our current fascism was previewed by progressive/POC critics of Reagan, Thatcher, Bush(es). Set post-fascist takeover, w/a choleric Hitlerian dictator enriched by corruption & profit off a plague released to scapegoat "outsiders" & spread fear.