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shonin, to random
@shonin@mastodon.world avatar

Clean air outperforms both is my guess >>

New data show Paxlovid outperforms molnupiravir against severe COVID-19 outcomes | CIDRAP

https://www.cidrap.umn.edu/covid-19/new-data-show-paxlovid-outperforms-molnupiravir-against-severe-covid-19-outcomes

trendless,
@trendless@zeroes.ca avatar

@shonin I think you just might be right on the money 👌

kimlockhartga, to random
@kimlockhartga@beige.party avatar
trendless,
@trendless@zeroes.ca avatar

@kimlockhartga @currentbias afaik, group A is and always has been very common. Seems like the word 'invasive' is being misconstrued by those reporting on this -- it doesn't indicate anything unique about the virus, but that an infection has progressed beyond the most common strep throat / impetigo presentations, gotten past the immune system and into the blood/organs where it can wreak havoc like septicemia, TSS, pneumonia, etc. This would be highly comorbid with impairment of the immune system, as is often seen post virally. For an intracellular pathogen like strep A to go rogue like this, it could indicate exhaustion or destruction of the CD8 T cell population. Not good.

dyckron, to random
@dyckron@mstdn.ca avatar

Rogers wants to offload nine data centres to reduce Shaw merger debt: report
https://mobilesyrup.com/2024/03/20/rogers-offload-nine-data-centres-reduce-shaw-debt-report/

trendless,
@trendless@zeroes.ca avatar

@dyckron fewer jobs, higher prices. Everyone saw it coming yet the govt did nothing.

O Canada, land of regulatory capture.

BE, to random
@BE@qoto.org avatar

Hello tech folks! This is perhaps a bit of an edge case for a residential setup, and maybe more along some commercial ones, but I am moving to a cabin in the woods. In these woods, there's a meadow of a few acres in which our cabin, a separate building that will be my wife's office, and a greenhouse are located. Due to the national forest networking, we have fantastic, symmetrical fiber optic internet service.

The "office" building is about 85 feet from the main cabin, just slightly above it, elevation wise. The greenhouse is about 125 feet away, and up maybe 40 feet in elevation.

I've twisted myself in knots trying to decide what outdoor unit to deploy at the main cabin. We already have a pole that currently has an old antenna, with coax coming off, doing nothing. I don't think it ever did anything down at the bottom of the valley it's in. I think that was a wishful thinking deployment by someone back in the day.

My thought, as a noob here, was something like a Ubiquiti U6 mesh with indoor APs in the indoor spaces. I'm running a Firewalla as a router, and would like to set up some VLANs.

Am I way off here thinking that a residential-type solution will work for me here? I just don't have the real world experience here to know if I'm researching the right path or not.

trendless,
@trendless@zeroes.ca avatar

@BE the pole will definitely help squeeze out every last bit of range. I tend to overspec range, too, though it doesn't seem they've got a wifi 6 version of their max range outdoor AP.

Could also get the kids building cantennas 👌

maleve, to random
@maleve@zeroes.ca avatar

Ok, so back to these new bare trust rules.

Something just feels wrong about how this is rolling out. It’s convoluted and unclear, and having asked the CRA and been told to seek the advice of a tax attorney it all seems wrong.

Journalists thankfully have written a few peices that in combination with the CRA docs can make some sense for the average person.

With these there pages you’d be well on your way in understanding the new requirements.

https://www.canada.ca/en/revenue-agency/services/tax/trust-administrators/t3-return/new-trust-reporting-requirements-t3-filed-tax-years-ending-december-2023.html

https://www.moneysense.ca/columns/ask-a-planner/what-new-bare-trust-tax-filing-rules-mean-for-canadians/

https://www.theglobeandmail.com/investing/personal-finance/taxes/article-a-how-to-for-people-caught-up-in-cras-confusing-new-rules-for/

trendless,
@trendless@zeroes.ca avatar

@maleve after CRA got slapped down for giving out provably false info on that line they've just decided to wash their hands of all responsibility; yknow, the govt/agency SOP of the YouDoYou™ '20s

Brad, to random
@Brad@zeroes.ca avatar

March 16, 2024- “I have spent hundreds of hours in the microscope looking at the worst viruses can do to the brain, including the Zika virus, HIV, Flu, and others. I've never seen the type of damage SARS-CoV-2 leaves behind after infection with other viruses.” - Danielle Beckman, Neuroscientist specialized in high- res microscopy. Pharm.D, M.S (Biophysics), Ph.D (Biological Chemistry).
https://www.daniellebeckman.com/about-me

trendless,
@trendless@zeroes.ca avatar

@Brad 🔥🔥🎯🎯

maleve, to random
@maleve@zeroes.ca avatar

Wife called CRA this morning wanting to clarify new rules and use a couple accounts as an example.

Went about as well as you would think.

  1. using this example do we need to report. Ans: I cannot comment
  2. is there someone at CRA that can answer this question. Ans: No

You need to hire a tax lawyer or accountant.

🤬🤬

The information out there is even the most innocent joint accounts, say birthday money for kids might need to be reported.

You can’t tell me you won’t answer the question and that I need to spend several hundred dollars to find out and non-compliance can be fines of thousands.

(1/)
https://zeroes.ca/@maleve/112112232233165410

trendless,
@trendless@zeroes.ca avatar

@maleve Someone suggested this is perhaps prelude to an estate tax? Like you said, govt should already have all the details of all the bank accounts and who has access, but maybe it's easier for them to have taxpayers collect and submit all this data to CRA -- save em a bunch of work.

🤮

18+ trendless, to random
@trendless@zeroes.ca avatar

How much of the ongoing pandemic is being motivated by an unwillingness to contend with one's own mortality?

18+ trendless, (edited )
@trendless@zeroes.ca avatar

@ikeruga I think I get what you're saying. I think that was my jumping off point, in fact: "I don't care if I die, I just wanna have fun" strikes me as dishonest in all but the most.. kamikaze. It's what people keep saying and I believe it less and less as I observe them more and more. Some may well have been scared in early 2020, but by and large seem to have dealt with it by averting their eyes, only too happy to embrace the cynical messaging that SARS-CoV-2 is either a cold or unavoidable, contrary to virtually all published science. I feel like an unwillingness to sincerely face and then integrate one's own vulnerability and mortality is not an entirely unexpected response to trauma.

18+ trendless,
@trendless@zeroes.ca avatar

@mastobit You've said it better than I 👌

trendless,
@trendless@zeroes.ca avatar

@mastobit 😂🤣 :chef_kiss:

subjacentish, to random
@subjacentish@zeroes.ca avatar

"BuT CoViD BrAIn DAmAgE ReSOLvEd EvEnTuAllY"

You can survive a metal pole being blown through your frontal lobe, giving you severe Aphasia.

You can even nearly completely recover from it. (Sort of; plasticity)

Still, I'd recommend not having a metal pole blown through your head, and if you gotta do it, do it only 1x.💀

trendless,
@trendless@zeroes.ca avatar
rolandelli, to random
@rolandelli@sfba.social avatar
trendless,
@trendless@zeroes.ca avatar
18+ trendless, to random
@trendless@zeroes.ca avatar

https://www.sciencedirect.com/science/article/pii/S2589537024000968

> Among 1900 recruited, a total of 995 participants completed the trial. No participants had clinical deterioration by day 9, 14, or 28 days among those treated with fluvoxamine plus bromhexine (0%), fluvoxamine plus cyproheptadine (0%), or niclosamide plus bromhexine (0%). Nine participants (5.6%) in the fluvoxamine arm had clinical deterioration by day 28, requiring low-flow oxygen. In contrast, most standard care arm participants had clinical deterioration by 9, 14, and 28 days.

> No deaths occurred in any study group. Compared to standard care, participants treated with the combination agents had significantly decreased viral loads as early as day 3 of treatment (p < 0.0001), decreased levels of serum cytokines interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β) as early as day 5 of treatment, and interleukin-8 (IL-8) by day 7 of treatment (p < 0.0001) and lower incidence of post-acute sequelae of COVID-19 (PASC) symptoms (p < 0.0001).

> Early treatment with these combinations among outpatients diagnosed with COVID-19 was associated with lower likelihood of clinical deterioration, and with significant and rapid reduction in the viral load and serum cytokines, and with lower burden of PASC symptoms. When started very soon after symptom onset, these repurposed drugs have high potential to prevent clinical deterioration and death in vaccinated and unvaccinated COVID-19 patients.

trendless, (edited )
@trendless@zeroes.ca avatar

@mcnado I suggest reading threads by the various authors, several of whom I've got years of history with and have come to trust over the course of the pandemic thus far. If there turn out to be issues with the study that peer review didn't catch, I've no doubt they'll address it.

https://twitter.com/farid__jalali/status/1768790993925722313?t=ZyOLDou_rkZbAIfR02W0hA&s=19

https://twitter.com/farid__jalali/status/1768418776998158600?t=A0BeQEiY9ogKu3To4XxtEQ&s=19

https://twitter.com/dr_leshan/status/1768435464640618835?t=1ROFGQpmnVbXOtdRb9CtVA&s=19

trendless, (edited ) to WFH
@trendless@zeroes.ca avatar

Desperate to hold onto their ever-shrinking workforce, but still unwilling to walk back their ignorance and lose face, Dell management thinks, “hey, let's screw our healthiest, most productive employees using whatever leverage we have left,” is the way?

> Dell Workers Can Stay Remote - But They're Not Going to Get Promoted https://ca.movies.yahoo.com/movies/dell-workers-stay-remote-mdash-110401493.html

trendless,
@trendless@zeroes.ca avatar

@croissant it's so [funny] to watch the exact same managerial disconnect from reality and lack of foresight that's been a primary driver of the ongoing pandemic shoot itself in the foot so obviously -- and this many years in, to boot.

trendless,
@trendless@zeroes.ca avatar

@Greengordon and the amount of discussion, commentary, and studies about it shows just how self aware they aren't, too. More decision based evidence making by people who whose feet are rarely if ever held to the fire.

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