@xtaldave@xtaldave.net
@xtaldave@xtaldave.net avatar

xtaldave

@xtaldave@xtaldave.net

Your friendly neighbourhood macromolecular crystallographer. Working on treatments for Cancer & Neurodegeneration.

Mediocre lefty bassist. Terrible guitarist. Laughable luthier. Fairphone Enjoyer. Xennial.

Born at 335 ppm. Go 💚 or go 🪦

May contain traces of hyperbole, sarcasm, and words.

Alt Profile: Street art of Donald Duck, dressed as Satan
Alt Banner: A glowing blue drug molecule bound to RET kinase domain

#Science #StructuralBiology #Crystallography #Bass #Mastodog #London #nobot

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xtaldave, to bass
@xtaldave@xtaldave.net avatar

This bass has an Ass. (It's a Caracal 034)
#Bass

xtaldave, to strucbio
@xtaldave@xtaldave.net avatar

:geordi_no: Alphafold3. Not FOSS. Not FAIR. Public version has important features redacted.

:geordi_ye: OpenFold: retraining AlphaFold2 yields new insights into its learning mechanisms and capacity for generalization | Nature Methods

Faster. FOSS. FAIR.

@strucbio

https://www.nature.com/articles/s41592-024-02272-z

xtaldave, to structbio
@xtaldave@xtaldave.net avatar

The AlphaFold3 Transparency and Reproducibility letter and signatories zenodo page

#StructuralBiology @structbio
https://zenodo.org/records/11192369

xtaldave, to strucbio
@xtaldave@xtaldave.net avatar

Open letter to Nature editors complaining about the lack of code availability for AF3 (Publishing code is normally a prerequisite for publishing in Nature)

(Yes, I am fully aware of the irony of using a Google form to do this - not my idea, just sharing.)

@strucbio

https://docs.google.com/forms/d/e/1FAIpQLSf6ioZPbxiDZy5h4qxo-bHa0XOTOxEYHObht0SX8EgwfPHY_g/viewform

xtaldave,
@xtaldave@xtaldave.net avatar

@markus They very much did

xtaldave,
@xtaldave@xtaldave.net avatar

@markus The worst part is that Nature let them get away with this, but the rest of us plebs are always required to show our working. Can't have a two tier system.

xtaldave,
@xtaldave@xtaldave.net avatar

@graemewinter @markus yup - it's only available by server with a Google login, 10 shots a day, limited functionality. It's not great.

xtaldave, to Georgia
@xtaldave@xtaldave.net avatar

She's singing about the sun and fire whilst a geomagnetic storm hits? Coincidence? #Georgia #Eurovision

xtaldave, to Eurovision
@xtaldave@xtaldave.net avatar

Gotta flog that merch .

xtaldave,
@xtaldave@xtaldave.net avatar

@DJDarren white ford transit in the parking lot.

xtaldave, to Eurovision
@xtaldave@xtaldave.net avatar

xtaldave, to Eurovision
@xtaldave@xtaldave.net avatar

The EBU is currently in a crisis meeting, according to information on SVT.

https://www.svt.se/kultur/senaste-nytt-om-eurovision-song-contest-2024

xtaldave, to random
@xtaldave@xtaldave.net avatar

BBC News: Sunak says it'll take time for people to feel better - BBC News

Yup. After the election when your fucking arse has been handed to you, and you've fucked off to silicon valley you rat-faced cunt.
https://www.bbc.co.uk/news/articles/cmm3gzz1dj3o

xtaldave, to science
@xtaldave@xtaldave.net avatar

They reconstructed 1 cubic millimetre of human brain. It contains 1.4 petabytes of electron microscopy data, 150,000,000 synapses. 57,000 neurons.

Huge amount of work. For 1 cubic mm. The Brain is hardcore.

A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution | Science https://www.science.org/doi/10.1126/science.adk4858

xtaldave, to science
@xtaldave@xtaldave.net avatar

Alphafold 3 server has dropped, kids. https://golgi.sandbox.google.com/about

Can do select small mols, PTMs, Nucleic acids and ions.

@strucbio

xtaldave,
@xtaldave@xtaldave.net avatar

@strucbio https://www.nature.com/articles/s41586-024-07487-w

Paper link.

xtaldave, to environment
@xtaldave@xtaldave.net avatar

Well, shit.

BBC News - Climate change: World's oceans suffer from record-breaking year of heat
https://www.bbc.co.uk/news/science-environment-68921215

xtaldave, to hamburg
@xtaldave@xtaldave.net avatar

People of Hamburg!
I shall be visiting Hamburg this weekend.
Ostensibly, this is for work (Friday) but I may have accidentally tacked on a couple of days extra to explore the city.

I now realise this is the weekend of the Harbour festival, so this is either a very good or a very bad weekend to visit (ymmv).

Suggestions for eateries (plant based) and other fun things to do gratefully accepted.

#Hamburg.

xtaldave,
@xtaldave@xtaldave.net avatar

EEEEEEP! The trip is in jeopardy! Due to the wonders of Brexit, our samples are currently stuck in customs in Belgium. As Thursday is a public holiday in BE and DE, if our (slowly thawing) samples don't make it to Hamburg tomorrow it is probably game over :sad_dog:

LALegault, to Israel
@LALegault@newsie.social avatar

xtaldave,
@xtaldave@xtaldave.net avatar

@LALegault "no choice but to assault a small city containing 1.4 million displaced people"

xtaldave, to random
@xtaldave@xtaldave.net avatar

Jesus, the fucking wheels are falling off now?

BBC News - Have the wheels come off for Tesla?
https://www.bbc.co.uk/news/business-68947020

xtaldave, to random
@xtaldave@xtaldave.net avatar

Happy Star Wars day to those who celebrate.

xtaldave, to random
@xtaldave@xtaldave.net avatar

Excellent work everyone

xtaldave,
@xtaldave@xtaldave.net avatar

Oh this is just chef's kiss.

(A quote from Scruffy McBumblecunt when the Blair government was looking at introducing ID cards)

xtaldave, to random
@xtaldave@xtaldave.net avatar

Anger as homophobic piece of shit George Galloway says gay relationships aren't 'normal'

“Three of my children go to a Catholic school in Scotland, so they have some protections for the moment,” -- ah yes, the catholic church, world renowned for absolutely 100% not abusing kids.

https://www.thepinknews.com/2024/05/02/george-galloway/

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