@trendless@zeroes.ca
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trendless

@trendless@zeroes.ca

Following those who have experience w/ chronic illness, those who are keeping up with the literature, and those sacrificing to keep us all safe; wearing P100 respiratory PPE, pursuing personal zero SARS-CoV-2

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bUt RiCh PeOpLe'S yAcHt MoNeY!! 🤪

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is burnin' up the charts

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https://www.sciencealert.com/rare-human-case-of-bubonic-plague-in-oregon-confirmed-by-authorities

• first case in the state in eight years; no deaths in decades

• officials suspect it was transmitted from a house cat that also showed symptoms

• progressed to the point of a rare [in modern times] outcome: "bubo", a draining abscess

• patient is apparently responding well to treatment, close contacts have also been treated to prevent spread

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https://www.nature.com/articles/s41598-024-53919-y

> One hundred post-COVID-19 patients and 76 healthy controls (pre-COVID-19) were included in this cross-sectional, case-controlled study. Participants' smell, taste, trigeminal, and salivary functions were assessed. The patients had a significantly higher prevalence of parosmia (80.0%), hyposmia (42.0%), anosmia (53.0%), dysgeusia (34.0%), complete ageusia (3.0%), specific ageusia (27.0%), dysesthesia (11.0%) and dry mouth (18.0%) compared to controls (0.0% for all parameters, except 27.6% for hyposmia). Complete loss of bitter taste was the most prevalent specific ageusia (66.7%) and coffee was the most common distorted smell (56.4%). Seven different combinations of dysfunction were observed in the patients, the most common being a combination of olfactory and gustatory dysfunction (48.0%).

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https://www.theguardian.com/environment/2024/feb/11/epa-reapprove-paraquat-herbicide-parkinsons

> Agency’s draft report backs paraquat’s safety but lawsuit’s plaintiffs say EPA ignored evidence of Parkinson’s risk

I mean, it'll be impossible to identify whether this or SARS is responsible, so I guess there's no risk of liability 🙃🫠

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> Jose L Jimenez et al. Indoor Air. 2022 Aug. https://pubmed.ncbi.nlm.nih.gov/36040283/

> The question of whether SARS-CoV-2 is mainly transmitted by droplets or aerosols has been highly controversial.

> For most of human history, the dominant paradigm was that many diseases were carried by the air, often over long distances and in a phantasmagorical way. This miasmatic paradigm was challenged in the mid to late 19th century with the rise of germ theory, and as diseases such as cholera, puerperal fever, and malaria were found to actually transmit in other ways. Motivated by his views on the importance of contact/droplet infection, and the resistance he encountered from the remaining influence of miasma theory, prominent public health official Charles Chapin in 1910 helped initiate a successful paradigm shift, deeming airborne transmission most unlikely. This new paradigm became dominant. However, the lack of understanding of aerosols led to systematic errors in the interpretation of research evidence on transmission pathways. For the next five decades, airborne transmission was considered of negligible or minor importance for all major respiratory diseases, until a demonstration of airborne transmission of tuberculosis (which had been mistakenly thought to be transmitted by droplets) in 1962. The contact/droplet paradigm remained dominant, and only a few diseases were widely accepted as airborne before COVID-19: those that were clearly transmitted to people not in the same room. The acceleration of interdisciplinary research inspired by the COVID-19 pandemic has shown that airborne transmission is a major mode of transmission for this disease, and is likely to be significant for many respiratory infectious diseases.

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https://fortune.com/2024/02/09/remote-work-jobs-disappearing-ringover-survey/

https://archive.is/ezLhk

> Across industries, U.S. work from home roles have shrunk by a quarter since 2021, new data from software firm Ringover finds.

> Forget the fact that nearly every expert insists that flexible work arrangements—guided principally by employee desires—are the way of the future. Disregard, too, the fact that many workers insist they’re more productive working from home—and more likely to feel empowered to do their best work under a boss who allows them to work where they want. And pretend you don’t know that return-to-office mandates are near-universally reviled and lead to rapid retention issues, bitter company culture, and swelling resentment—with worsened productivity to boot.

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https://medicalxpress.com/news/2024-02-dangerous-pregnancy-complications-linked-covid.html

> DNA changes consistent with life-threatening pregnancy complications have been found in the placentas of pregnant women infected by COVID-19, according to University of Queensland researchers. Their research paper is published in Clinical and Translational Immunology.

"Using digital spatial profiling, we discovered the virus disrupts placental function by altering the genomic architecture of the cells critical to providing nutrients and blood supply to unborn babies. We also found the DNA fingerprints of poor placental oxygenation, stress and pre-eclampsia in the COVID-19 patients."

🔗 Nataly Stylianou et al, Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures, Clinical & Translational Immunology (2024). DOI: 10.1002/cti2.1488

> We utilised whole-transcriptome, digital spatial profiling, to examine gene expression patterns in placental tissues from participants who contracted SARS-CoV-2 in the third trimester of their pregnancy (n = 7) and those collected prior to the start of the coronavirus disease 2019 (COVID-19) pandemic (n = 9).

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Masked protesters could soon face arrest, says Home Office

https://www.theguardian.com/uk-news/2024/feb/08/masked-protesters-could-soon-face-arrest-says-home-office

> Protesters who wear masks could face arrest, up to a month in jail and a £1,000 fine under proposed measures

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The absence of fear is not courage, but ignorance. Courage is action in the face of fear.

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MicroDenials™

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https://medicalxpress.com/news/2024-02-analysis-reveals-excess-deaths-attributed.html

> the study compared reported COVID-19 deaths to excess deaths due to non-COVID natural causes, such as diseases and chronic illnesses, and found that increases in non-COVID excess deaths occurred at the same time or in the month prior to increases in reported COVID-19 deaths in most US counties.

> Focusing on excess deaths by natural causes rather than all-cause excess death estimates provides a more accurate understanding of the true number of deaths attributable to COVID-19, as it eliminates external causes for mortality, such as intentional or unintentional injuries, for which COVID-19 would not be a contributing factor.

“Our findings show that many COVID-19 deaths went uncounted during the pandemic. Surprisingly, these undercounts persisted well beyond the initial phase of the pandemic"

🔗 Eugenio Paglino et al, Excess natural-cause mortality in US counties and its association with reported COVID-19 deaths, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2313661121

@novid

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Holy 🤬, that's some window shifting

> From measles to colds, seven common winter illnesses and what you need to do when they strike https://www.thesun.co.uk/health/25700333/common-winter-illnesses-health-tips/

**btw, measles is airborne

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When authorities decided to downplay the most contagious pathogen ever and the most severe pandemic threat in a hundred years, it was inevitable that they'd have to take that same position on all future pathogens and pandemic threats. Humanity is suffering for taking an absolutely irresponsible position and not being able to climb down from it. We will continue to suffer until we do.

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:n95: :vflex: :aura: :auraHCW: :xplore1900:

When you use a disposable filtering facepiece respirator (eg N95, FFP2), how often do you don it before you dispose of it?

@novid

1/3

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https://edmontonjournal.com/news/local-news/power-fail-alberta-energy-only-market-january-cold-snap-gridlock

> Of North American jurisdictions, Alberta shares its “energy-only” style of electricity grid production with no other provinces — and in the States, only with Texas

🫠

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I really don't understand what's causing these VOC spikes. They seem to be unrelated to any scents, cooking, diaper changes, etc. 🤔

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As if there needed to be another reason to look elsewhere for SBC gear..

RPi to IPO https://www.hackster.io/news/raspberry-pi-confirms-a-planned-ipo-but-says-hobbyists-will-remain-incredibly-important-f7b9625e0d52

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:micdrop:

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> As the global population ages, more and more research is focusing on the effects of multimorbidity: the presence of two or more long-term health conditions.

Yep, because it's going to be altogether too common.

🔗 With age, accumulating health problems can increase risk of depression and anxiety https://medicalxpress.com/news/2024-01-age-accumulating-health-problems-depression.html

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People are inclined to hide a contagious illness while around others, research shows https://www.sciencedaily.com/releases/2024/01/240129182421.htm

> Across a series of studies involving healthy and sick adults, 75% of the 4,110 participants said they had either hidden an infectious illness from others at least once or might do so in the future.

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Beware post-acute cardiac issues, even if standard tests indicate everything's fine 😬 :heart_anatomical:

> Despite the paucisymptomatic presentation of COVID-19 infection and the absence of relevant anomalies in standard first-level diagnostic investigations, echocardiographic examination findings especially speckle tracking analysis (global longitudinal strain) along with some clinical aspects suggested further second-level investigations eventually allowing the identification of inflammatory myocardial damage.

🔗 Paucisymptomatic post COVID-19 myocarditis in a young athlete during return to play workflow: possible usefulness of global longitudinal strain analysis https://casereports.bmj.com/content/17/1/e255863

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