trendless

ckkellymartin, 2 months ago to random

A bit of an update to the Cineplex facial recognition/demanding masks be removed issue. I was at their Lansdowne theatre a couple of months ago to watch All of Us Strangers, obviously before this policy was adopted. But I won't be going back there, or to any Cineplex, while this policy exists.

trendless, 2 months ago to random

Register to be a 🇨🇦 FluWatcher

https://cnphi.canada.ca/fluWatcher/register

Currently <500 in :flag_AB:

trendless, 3 months ago to random

https://www.nature.com/articles/s41598-024-54613-9

> We enrolled 33 post-COVID patients, all self-reporting cognitive difficulties, and a matched control group (N = 27) for cognitive and psychological assessments. Our findings revealed significant attention deficits in post-COVID patients across both neuropsychological measurements and experimental cognitive tasks, evidencing reduced performance in tasks involving interference resolution and selective and sustained attention. Mild executive function and naming impairments also emerged from the neuropsychological assessment. Notably, 61% of patients reported significant prospective memory failures in daily life, aligning with our recruitment focus. Furthermore, our patient group showed significant alterations in the psycho-affective domain, indicating a complex interplay between cognitive and psychological factors, which could point to a non-cognitive determinant of subjectively experienced cognitive changes following COVID-19.

trendless, 2 months ago to random

Viral infections pose early heart risks

> "From a clinical perspective, our understanding of viral infection of the heart has focused on inflammation, causing problems with the rate or rhythm of the heartbeat… But we have found an acute stage when the virus first infects the heart and before the body's immune response causes inflammation. So even before the tissue is inflamed, the heart is being set up for arrhythmia."

https://www.sciencedaily.com/releases/2024/03/240306203111.htm

trendless, 3 months ago (edited 3 months ago) to WFH

https://fortune.com/2024/02/09/remote-work-jobs-disappearing-ringover-survey/

https://archive.is/ezLhk

> Across industries, U.S. work from home roles have shrunk by a quarter since 2021, new data from software firm Ringover finds.

> Forget the fact that nearly every expert insists that flexible work arrangements—guided principally by employee desires—are the way of the future. Disregard, too, the fact that many workers insist they’re more productive working from home—and more likely to feel empowered to do their best work under a boss who allows them to work where they want. And pretend you don’t know that return-to-office mandates are near-universally reviled and lead to rapid retention issues, bitter company culture, and swelling resentment—with worsened productivity to boot.

#RTO #WFH

trendless, 3 months ago to random

MicroDenials™

trendless, 3 months ago to random

https://www.nature.com/articles/s41591-023-02793-8

> Following the observation that higher circulating levels of metabolites derived from niacin—an essential micronutrient that is fortified in cereals—are associated with a higher risk for cardiovascular events, genetic and preclinical studies established links among niacin-derived metabolites, soluble vascular adhesion molecule 1 levels and leukocyte adhesion to the vascular endothelium.

trendless, 3 months ago (edited 3 months ago) to random

https://www.eurekalert.org/news-releases/1034588

> A gut microbial metabolite called 2-methylbutyrylcarnitine (2MBC) plays a role in exacerbating thrombosis -- the formation of blood clots... The results also revealed that 2MBC is accumulated in individuals with COVID-19, potentially explaining why these patients are at increased risk of thrombosis.

🔗 Cell Metabolism, Huang, Li, He, Dai, Huang, and Shi et al.: “Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin a2b1” https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00014-7

trendless, 3 months ago to random

https://www.medrxiv.org/content/10.1101/2024.02.11.24302636v1

> To maximize our chances of identifying the underpinnings of this illness, we have focused on 121 of the most severe cases from >1000 patients screened in specialized clinics in Sweden and Belgium. We restricted this study to subjects with objective measures of organ damage or dysfunction, >3 months following a verified, but mild-to-moderate SARS-CoV-2 infection. By performing systems-level immunological testing and comparisons to controls fully convalescent following a similar mild/moderate COVID-19 episode, we identify elevated serological responses to SARS-CoV-2 in severe Long COVID suggestive of chronic antigen stimulation. Persistent viral reservoirs have been proposed in Long COVID and using multiple orthogonal methods for detection of SARS-CoV-2 RNA and protein in plasma we identify a subset of patients with detectable antigens, but with minimal overlap across assays, and no correlation to symptoms or immune measurements. Elevated serologic responses to SARS-CoV-2 on the other hand were inversely correlated with clonally expanded memory CD8+ T cells, indicating that restrained clonal expansion enables viral persistence, chronic antigen exposure and elevated IgG responses, even if antigen-detection in blood is not universally possible.

trendless, 2 months ago (edited 2 months ago) to random

Then stop carrying water for the powerful interests who continue to force it on us and acknowledge it's causes are [state-sponsored] denial and neurological damage. 😤

⛔⛽🔥

#CovidIsNotOver

> We need to take our post-pandemic mental health crisis seriously
https://thehill.com/opinion/4534908-we-need-to-take-our-post-pandemic-mental-health-crisis-seriously/

trendless, 3 months ago to novid

https://www.science.org/doi/10.1126/sciadv.adi9379

> Patients with Long Covid symptoms produce an antiviral protein called interferon-γ persistently until their symptoms resolve.

Abstract: after acute infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a proportion of patients experience persistent symptoms beyond 12 weeks, termed Long Covid. Understanding the mechanisms that cause this debilitating disease and identifying biomarkers for diagnostic, therapeutic, and monitoring purposes are urgently required. We detected persistently high levels of interferon-γ (IFN-γ) from peripheral blood mononuclear cells of patients with Long Covid using highly sensitive FluoroSpot assays. This IFN-γ release was seen in the absence of ex vivo peptide stimulation and remains persistently elevated in patients with Long Covid, unlike the resolution seen in patients recovering from acute SARS-CoV-2 infection. The IFN-γ release was CD8+ T cell–mediated and dependent on antigen presentation by CD14+ cells. Longitudinal follow-up of our study cohort showed that symptom improvement and resolution correlated with a decrease in IFN-γ production to baseline levels. Our study highlights a potential mechanism underlying Long Covid, enabling the search for biomarkers and therapeutics in patients with Long Covid.

#LongCovid @novid

trendless, 1 month ago to random

https://threadreaderapp.com/thread/1775607000174383323.html

“I think if someone’s going to make a claim like ‘Covid doesn’t harm your immune system’, that’s a bold claim.

The claim itself is contrarian, as it flies in the face of the established science. It’s beyond meaningful debate at this point that some cases of Covid -even mild ones- lead to depletion of immune system components for months.

The people who would have us believe that this is no cause for concern base their argument on the fact that it (a) only happens to some people, (b) only happens for a little while or (c) happens with other viruses as well. All three statements are true. And irrelevant here.

This is a disease that most people can expect to get multiple times in their lives (our modeling suggests 1-2x/yr, in the absence of precautions), cumulative damage is well documented for other organ systems. Some -very nonzero - fraction of infections is persistent as well.

There’s no evidence suggesting that some people are uniquely vulnerable to immune depletion while others aren’t. It’s a Russell’s teapot to make the claim, and those who make it should produce the evidence to support it.

If you get the disease once a year and your immune system spends 6 months recovering each time, you are functionally immunocompromised- on average- when you look at it across the entire year.

Repeated infections cause cumulative damage & intrahost viral evolution during persistent infections leading to immune evasion is well documented. Those who make the claim that such intrahost evo during persistent infections is rare should produce evidence to support it.

False analogies to other viruses have been used by minimizers to confuse the issue from the get-go. Covid is not HIV, the flu or a cold. It’s an unprecedented public health threat, and the claim that there is no cause for concern is speculative.”

-- @arijitchakrav

trendless, 2 months ago to random

Are. You. Kidding. Me.

> Canadian Banks are Pushing for the Bank of Canada to Remove Shelter Costs From CPI https://thenorthernaccount.ca/canadian-banks-are-pushing-for-the-bank-of-canada-to-remove-shelter-costs-from-cpi/

trendless, 3 months ago to random

The absence of fear is not courage, but ignorance. Courage is action in the face of fear.

trendless, 3 months ago (edited 3 months ago) to random

For anyone who wants to help test, I'd like to trial using Matrix for a voice chat at some point this weekend. If you've got an account on #ZeroesCA, you can get on https://talk.zeroes.ca without much friction. For folks elsewhere, all you need is a Matrix account on a federated server.

#CovidIsNotOver

trendless, 2 months ago (edited 2 months ago) to covid

:auraHCW: :n95:

Vitacore's having a RIDICULOUS clearance sale on a few 3M respirators; in particular, a case of Aura 1870+ is as cheap as I've ever seen it (or any other Aura, for that matter) -- works out to $0.70/ea

https://shop.vitacore.ca/collections/clearance?mc_cid=ffaa239e69

🇨🇦 #MaskUp #BetterMasks #N95 #CovidIsAirborne @covid @covid19 @covidisairborne

trendless, 3 months ago to random

Do cancer patients hospitalized in BC get tested for scv2 if/when they develop a URI?

trendless, 2 months ago to random

Adherence to cultural norms/expectations is not the same as being considerate of others.

trendless, 3 months ago to random

https://www.sciencealert.com/rare-human-case-of-bubonic-plague-in-oregon-confirmed-by-authorities

• first case in the state in eight years; no deaths in decades

• officials suspect it was transmitted from a house cat that also showed symptoms

• progressed to the point of a rare [in modern times] outcome: "bubo", a draining abscess

• patient is apparently responding well to treatment, close contacts have also been treated to prevent spread

trendless, 3 months ago to random

Daisugi – Growing Straight Lumber Without Killing The Tree https://hackaday.com/2024/02/20/daisugi-growing-straight-lumber-without-killing-the-tree/

trendless, 3 months ago (edited 3 months ago) to random

https://medicalxpress.com/news/2024-02-dangerous-pregnancy-complications-linked-covid.html

> DNA changes consistent with life-threatening pregnancy complications have been found in the placentas of pregnant women infected by COVID-19, according to University of Queensland researchers. Their research paper is published in Clinical and Translational Immunology.

"Using digital spatial profiling, we discovered the virus disrupts placental function by altering the genomic architecture of the cells critical to providing nutrients and blood supply to unborn babies. We also found the DNA fingerprints of poor placental oxygenation, stress and pre-eclampsia in the COVID-19 patients."

🔗 Nataly Stylianou et al, Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures, Clinical & Translational Immunology (2024). DOI: 10.1002/cti2.1488

> We utilised whole-transcriptome, digital spatial profiling, to examine gene expression patterns in placental tissues from participants who contracted SARS-CoV-2 in the third trimester of their pregnancy (n = 7) and those collected prior to the start of the coronavirus disease 2019 (COVID-19) pandemic (n = 9).

trendless, 2 months ago to random

https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00372-5/fulltext?s=09

> We propose that prolonged detection of WI-CL-001 in wastewater indicates persistent shedding of SARS-CoV-2 from a single human initially infected by an ancestral B.1.234 virus. The accumulation of convergent omicron-like mutations in WI-CL-001’s ancestral B.1.234 genome probably reflects persistent infection and extensive within-host evolution. People who shed cryptic lineages could be an important source of highly divergent viruses that sporadically emerge and spread.

#CovidIsNotOver

trendless, 3 months ago to random

Did the AMTA (Alberta Motor Transit Authority) just appoint Stephen Harper's brother president and then immediately pivot to trumpeting the success of the hydrogen truck pilot being run for the past year by Nikola and Bison?

🤔🧐

Lorrrraaaaine, 3 months ago to random

Uhhhhh. Hmmmm. Who’s going to tell them?

Not me.

The comments are wild.

They’re never going to put 2 + 2 together. Like literally never.

It doesn’t matter how much science or #CovidPapers you give them on a silver platter, they will believe the most insanest theories vs the logical one

Honestly think people were smarter during the Dark Ages given what they had to work with🤦🏻‍♀️

trendless, 3 months ago (edited 3 months ago) to random

Wanna save healthcare? Start wearing a mask and ask that your providers do, too.

Simple as.